COSMIS
Scores how tolerant each amino acid site is to missense variation from the population constraint on the site and its 3D contact neighbours in the protein structure (contact set missense tolerance).
Results are recorded on linked configurations and versions of this method. Their settings and evaluations are kept separate below.
Results on linked records
This method has no results of its own in this release. One linked record has results. They are not assigned to the underlying method: each record keeps its own settings and evaluations, and its scores are on its own page.
- COSMIS (Livesey and Marsh 2025) Configuration · configuration · 1 evaluation · 1 result
Overview
An explanatory profile has not yet been reviewed for this record.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
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How it works, versions and access
Strengths, limitations and unresolved questions
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
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One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Livesey and Marsh 2025, Supplementary Material 2 (Tables S1-S8) · Original source · 13059_2025_3575_MOESM2_ESM.xlsx as published with PMC12016141
Technical metadata and extraction receipts
Stable ID: vep-lit-20261014-method-cosmis
- areas
- dna-genomes; proteins-complexes
- contexts
- research; clinical_research
- method types
- specialist
- reported name
- COSMIS
- entity level
- method
- source locator
- Supplementary Material 2, Table S8 column A ('COSMIS')
- missing metadata
- version: reason: inapplicable; note: Family record; score versions are on configurations
- review
- reviewer: claude; reviewer note: Claude review agent; no human review claimed. Independent Claude (Opus 5.5) review agent, separate from the extraction agent that built this batch. Automated review only. Transcription, not reproduction.; reviewed at: 2026-10-14T15:30:00Z; artifact sha256: 1b0d792d1a5d3daa95545a7973cabb131c45e42c952e7e5a447a72deef1d1e70; retrieval url: https://static-content.springer.com/esm/art%3A10.1186%2Fs13059-025-03575-w/MediaObjects/13059_2025_3575_MOESM2_ESM.xlsx; method: ai-assisted-source-review; scope-review; method note: Descriptive fields, identity links and missing-metadata reasons checked against the cited sources.; note: Checked; see the dated review for rulings on identity and method type.
- provenance note
- Scored in the clinical ranking of Livesey and Marsh 2025 (Table S8, row 'COSMIS'). The paper's VEP list (Table S2) and text do not describe it.
Related records
- configuration of: COSMIS (Livesey and Marsh 2025)