ClairS-TO
Deep-learning tumour-only somatic small-variant caller that combines an affirmative and a negational neural network, with panels of normals and hard filters.
Results are recorded on linked configurations and versions of this method. Their settings and evaluations are kept separate below.
Results on linked records
This method has no results of its own in this release. 7 linked records have results. They are not assigned to the underlying method: each record keeps its own settings and evaluations, and its scores are on its own page.
- ClairS-TO SS v0.4.0, tumour-only, Illumina (Chen et al. 2025) Configuration · configuration · 2 evaluations · 14 results
- ClairS-TO SS v0.4.0, tumour-only, ONT (Chen et al. 2025) Configuration · configuration · 4 evaluations · 84 results
- ClairS-TO SS v0.4.0, tumour-only, PacBio HiFi (Chen et al. 2025) Configuration · configuration · 2 evaluations · 14 results
- ClairS-TO SSRS v0.4.0, tumour-only, Illumina (Chen et al. 2025) Configuration · configuration · 2 evaluations · 14 results
- ClairS-TO SSRS v0.4.0, tumour-only, ONT (Chen et al. 2025) Configuration · configuration · 4 evaluations · 84 results
- ClairS-TO SSRS v0.4.0, tumour-only, PacBio HiFi (Chen et al. 2025) Configuration · configuration · 2 evaluations · 14 results
- ClairS-TO v0.4.0, tumour-only Illumina WGS (Krishnamachari et al. 2026) Configuration · configuration · 6 evaluations · 17 results
Overview
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Evidence
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Evidence table
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- ClairS-TO: a deep-learning method for long-read tumor-only somatic small variant calling · Original source · Nature Communications, published 2025-10-31; PMC12579226 full-text XML
Technical metadata and extraction receipts
Stable ID: somatic-clairs-to-20261011-method-clairs-to
- areas
- dna-genomes
- contexts
- clinical_research
- method types
- supervised_machine_learning
- reported name
- ClairS-TO
- entity level
- method
- source locator
- Results 'Overview of ClairS-TO'; Methods
- missing metadata
- version: reason: inapplicable; note: Family record; versions are on configurations
Related records
- configuration of: ClairS-TO SS v0.4.0, tumour-only, Illumina (Chen et al. 2025)
- configuration of: ClairS-TO SS v0.4.0, tumour-only, ONT (Chen et al. 2025)
- configuration of: ClairS-TO SS v0.4.0, tumour-only, PacBio HiFi (Chen et al. 2025)
- configuration of: ClairS-TO SSRS v0.4.0, tumour-only, Illumina (Chen et al. 2025)
- configuration of: ClairS-TO SSRS v0.4.0, tumour-only, ONT (Chen et al. 2025)
- configuration of: ClairS-TO SSRS v0.4.0, tumour-only, PacBio HiFi (Chen et al. 2025)
- configuration of: ClairS-TO v0.4.0, tumour-only Illumina WGS (Krishnamachari et al. 2026)