Glide
Physics-based molecular docking program that generates and scores protein-ligand poses at standard precision (SP) and extra precision (XP).
Results are recorded on linked configurations and versions of this method. Their settings and evaluations are kept separate below.
Results on linked records
This method has no results of its own in this release. 6 linked records have results. They are not assigned to the underlying method: each record keeps its own settings and evaluations, and its scores are on its own page.
- Glide_SP docking baseline Configuration · configuration · 2 evaluations · 22 results
- Glide_SP on DEKOIS 2.0, values quoted by Shen et al. 2025 Configuration · configuration · 1 evaluation · 10 results
- Glide_SP rescoring of AF3 top-ranked poses Configuration · configuration · 1 evaluation · 10 results
- Glide_SP rescoring of Protenix top-ranked poses Configuration · configuration · 2 evaluations · 20 results
- Glide_XP rescoring of AF3 top-ranked poses Configuration · configuration · 1 evaluation · 10 results
- Glide_XP rescoring of Protenix top-ranked poses Configuration · configuration · 2 evaluations · 20 results
Overview
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How it works, versions and access
Strengths, limitations and unresolved questions
Evidence
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Evidence table
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Shen et al. 2025, Chemical Science (Europe PMC full text) · Original source · PMC12704515 (Chem Sci, published 2025-12-11)
Technical metadata and extraction receipts
Stable ID: hitdisc-20261022-method-glide
- areas
- molecular-interactions
- contexts
- research
- method types
- conventional_pipeline
- entity level
- method
- reported name
- Glide
- version
- Implemented in Schrodinger version 2020-4 as used by Shen et al. 2025
- access
- Commercial (Schrodinger); no access terms are stated in the source
- source locator
- Methods 'Glide'; Results 'Evaluation of AF3's built-in confidence scores on DEKOIS2.0 dataset'
- provenance note
- Created from the comparator description in Shen et al. 2025; the Glide primary papers (refs 27 and 65 of that source) were not retrieved.
- review
- method: scope-review; automated-source-review; reviewer: claude; reviewer note: Claude review agent, independent of the extraction agent; no human review claimed; date: 2026-10-22; method note: Read the record against the pinned sources and against docs/use-cases.md and docs/record-contract.md.; note: Record checked against the pinned source and the record contract. Transcription checked; not reproduced and not reviewed by a human scientist.; artifact sha256: 11a4cee97057d9e72f9393024d22fdd169e3134f493367eee2f7869facf9ccf8; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12704515/fullTextXML; receipt: data/omics/use-case-coverage-hitdisc-20261022/review.json
Related records
- configuration of: Glide_SP docking baseline
- configuration of: Glide_SP on DEKOIS 2.0, values quoted by Shen et al. 2025
- configuration of: Glide_SP rescoring of AF3 top-ranked poses
- configuration of: Glide_SP rescoring of Protenix top-ranked poses
- configuration of: Glide_XP rescoring of AF3 top-ranked poses
- configuration of: Glide_XP rescoring of Protenix top-ranked poses