Evaluation

OUTRIDER on the NIH neuromuscular diagnosed RNA-seq truth set (expression)

Published comparison transcribed from the pinned source; not reproduced.

Evaluation results

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Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

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Readiness checks, gaps and artifacts

Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

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Investigate discrepancies

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Missing or unresolved evidence

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Run locally

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Validate independently

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No verified artifact manifest is linked to this exact record.
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Evaluation procedure

Recovery of known expression-outlier genes and outlier calls in true-negative samples, patient RNA-seq (Silverstein et al. Table S9, OUTRIDER)

Dataset: NIH neuromuscular diagnosed RNA-seq truth set (Silverstein et al. 2026)

origin: Independent external evaluation
configuration: Primary source as retrieved 2026-10-11
dataset version: NIH neuromuscular diagnosed RNA-seq truth set (dbGaP phs001272.v2.p1), as published
split: No split
population: 15 known expression-outlier genes (14 muscle, 1 fibroblast); 9 true-negative samples
inputs: Patient tissue RNA-seq aligned with STAR to GRCh38 (GTEx v10 pipeline); tool-specific controls as in parameters
adaptation: Not reported
metric implementation: Spreadsheet formulas over TP, FN, TN and FP (Table S9); MCC from the binary confusion matrix
aggregation: Sum over tissue sets
budget: Not reported
protocol id: rna-splicing-20261011-silverstein2026-protocol-expression

Metadata review: needs review. Unreported conditions prevent automatic comparisons.

Reproduction

Split: No split
Adaptation: Not reported
Scoring implementation: Spreadsheet formulas over TP, FN, TN and FP (Table S9); MCC from the binary confusion matrix

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

36 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Comparison: adaptation Not reported Context-only references	Benchmarking RNA-seq Tools for Real-World Diagnostic Applications (Silverstein et al., medRxiv 2026) Original source ↗ Table S9 row 7 ('OUTRIDER') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: medRxiv preprint version 1, posted 2026-01-28; JATS source XML Retrieved: 2026-10-11T21:38:32Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.adaptation` Source artifact SHA-256: `8b987ac49f086adc0a191522436529a70f243505f7dda9926786004e15b4601c` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: adaptation Not reported Context-only references	Silverstein et al. 2026 Supplemental Tables S1-S10 (medRxiv media-3.xlsx) Original source ↗ Table S9 row 7 ('OUTRIDER') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: medRxiv preprint version 1 supplement DC3 (file 344940_file09.xlsx in the JATS XML) Retrieved: 2026-10-11T21:38:52Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.adaptation` Source artifact SHA-256: `3d137444b13225cf1223ad73758fdfcb4b5f772263e0aafd827d8ca57ca00120` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: aggregation Sum over tissue sets Context-only references	Benchmarking RNA-seq Tools for Real-World Diagnostic Applications (Silverstein et al., medRxiv 2026) Original source ↗ Table S9 row 7 ('OUTRIDER') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: medRxiv preprint version 1, posted 2026-01-28; JATS source XML Retrieved: 2026-10-11T21:38:32Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.aggregation` Source artifact SHA-256: `8b987ac49f086adc0a191522436529a70f243505f7dda9926786004e15b4601c` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: aggregation Sum over tissue sets Context-only references	Silverstein et al. 2026 Supplemental Tables S1-S10 (medRxiv media-3.xlsx) Original source ↗ Table S9 row 7 ('OUTRIDER') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: medRxiv preprint version 1 supplement DC3 (file 344940_file09.xlsx in the JATS XML) Retrieved: 2026-10-11T21:38:52Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.aggregation` Source artifact SHA-256: `3d137444b13225cf1223ad73758fdfcb4b5f772263e0aafd827d8ca57ca00120` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: budget Not reported Context-only references	Benchmarking RNA-seq Tools for Real-World Diagnostic Applications (Silverstein et al., medRxiv 2026) Original source ↗ Table S9 row 7 ('OUTRIDER') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: medRxiv preprint version 1, posted 2026-01-28; JATS source XML Retrieved: 2026-10-11T21:38:32Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.budget` Source artifact SHA-256: `8b987ac49f086adc0a191522436529a70f243505f7dda9926786004e15b4601c` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: budget Not reported Context-only references	Silverstein et al. 2026 Supplemental Tables S1-S10 (medRxiv media-3.xlsx) Original source ↗ Table S9 row 7 ('OUTRIDER') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: medRxiv preprint version 1 supplement DC3 (file 344940_file09.xlsx in the JATS XML) Retrieved: 2026-10-11T21:38:52Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.budget` Source artifact SHA-256: `3d137444b13225cf1223ad73758fdfcb4b5f772263e0aafd827d8ca57ca00120` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: dataset version NIH neuromuscular diagnosed RNA-seq truth set (dbGaP phs001272.v2.p1), as published Context-only references	Benchmarking RNA-seq Tools for Real-World Diagnostic Applications (Silverstein et al., medRxiv 2026) Original source ↗ Table S9 row 7 ('OUTRIDER') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: medRxiv preprint version 1, posted 2026-01-28; JATS source XML Retrieved: 2026-10-11T21:38:32Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.dataset_version` Source artifact SHA-256: `8b987ac49f086adc0a191522436529a70f243505f7dda9926786004e15b4601c` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: dataset version NIH neuromuscular diagnosed RNA-seq truth set (dbGaP phs001272.v2.p1), as published Context-only references	Silverstein et al. 2026 Supplemental Tables S1-S10 (medRxiv media-3.xlsx) Original source ↗ Table S9 row 7 ('OUTRIDER') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: medRxiv preprint version 1 supplement DC3 (file 344940_file09.xlsx in the JATS XML) Retrieved: 2026-10-11T21:38:52Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.dataset_version` Source artifact SHA-256: `3d137444b13225cf1223ad73758fdfcb4b5f772263e0aafd827d8ca57ca00120` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: inputs Patient tissue RNA-seq aligned with STAR to GRCh38 (GTEx v10 pipeline); tool-specific controls as in parameters Context-only references	Benchmarking RNA-seq Tools for Real-World Diagnostic Applications (Silverstein et al., medRxiv 2026) Original source ↗ Table S9 row 7 ('OUTRIDER') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: medRxiv preprint version 1, posted 2026-01-28; JATS source XML Retrieved: 2026-10-11T21:38:32Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.inputs` Source artifact SHA-256: `8b987ac49f086adc0a191522436529a70f243505f7dda9926786004e15b4601c` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: inputs Patient tissue RNA-seq aligned with STAR to GRCh38 (GTEx v10 pipeline); tool-specific controls as in parameters Context-only references	Silverstein et al. 2026 Supplemental Tables S1-S10 (medRxiv media-3.xlsx) Original source ↗ Table S9 row 7 ('OUTRIDER') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: medRxiv preprint version 1 supplement DC3 (file 344940_file09.xlsx in the JATS XML) Retrieved: 2026-10-11T21:38:52Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.inputs` Source artifact SHA-256: `3d137444b13225cf1223ad73758fdfcb4b5f772263e0aafd827d8ca57ca00120` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: needs review

2 source records and release history

Benchmarking RNA-seq Tools for Real-World Diagnostic Applications (Silverstein et al., medRxiv 2026) · Original source · medRxiv preprint version 1, posted 2026-01-28; JATS source XML
Silverstein et al. 2026 Supplemental Tables S1-S10 (medRxiv media-3.xlsx) · Original source · medRxiv preprint version 1 supplement DC3 (file 344940_file09.xlsx in the JATS XML)

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Technical metadata and extraction receipts

Stable ID: rna-splicing-20261011-silverstein2026-eval-outrider

areas: rna-transcriptomes
contexts: clinical_research
origin: independent_paper
protocol: rna-splicing-20261011-silverstein2026-protocol-expression
version: Primary source as retrieved 2026-10-11
comparison: dataset version: NIH neuromuscular diagnosed RNA-seq truth set (dbGaP phs001272.v2.p1), as published; split: No split; population: 15 known expression-outlier genes (14 muscle, 1 fibroblast); 9 true-negative samples; inputs: Patient tissue RNA-seq aligned with STAR to GRCh38 (GTEx v10 pipeline); tool-specific controls as in parameters; adaptation: Not reported; metric implementation: Spreadsheet formulas over TP, FN, TN and FP (Table S9); MCC from the binary confusion matrix; aggregation: Sum over tissue sets; budget: Not reported; protocol id: rna-splicing-20261011-silverstein2026-protocol-expression
source locator: Table S9 row 7 ('OUTRIDER')
missing metadata: comparison.adaptation: reason: inapplicable; note: No model training or tuning on the truth set; comparison.budget: reason: unreported

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