rewirebio.iobenchmarks
Evaluation

GPN (human) (Self-supervised pre-training) on CAGI5 K562

Published comparison; transcribed, not reproduced.

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Release 2026-10-10-6e93f504adfc · Evidence verified: Not verified

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Investigate discrepancies

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Verified: Not verified

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Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: GPN (human), Self-supervised pre-training (Tang et al. 2025)Protocol: CAGI5 saturation MPRA variant effect correlation, K562 (Tang et al. 2025 Table 1)
Dataset: CAGI5 saturation mutagenesis MPRA, four CREs (as used by Tang et al. 2025)
0.037 pearson-correlation
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

GPN (human) (Self-supervised pre-training) on CAGI5 K562

regulatory-variant-20261009-protocol-tang2025-cagi5-k562

Aggregation: Not reported

Evaluating the representational power of pre-trained DNA language models for regulatory genomics · Table 1 row 'Self-supervised pre-training' / 'GPN (human)', column 'K562'

Source checking is not independent reproduction. Release 2026-10-10-6e93f504adfc.

Evaluation procedure

regulatory-variant-20261009-protocol-tang2025-cagi5-k562

Configuration
GPN (human), Self-supervised pre-training (Tang et al. 2025)
Protocol
CAGI5 saturation MPRA variant effect correlation, K562 (Tang et al. 2025 Table 1)
Dataset
CAGI5 saturation mutagenesis MPRA, four CREs (as used by Tang et al. 2025)
origin
Independent external evaluation
configuration
Primary source as retrieved 2026-10-09
dataset version
CAGI5 regulation challenge data
split
Zero-shot test
population
PKLR (K562)
inputs
230 nt sequence centred on the CRE
adaptation
Zero-shot: cosine similarity of embeddings for mutant and wild-type sequence (NT, HyenaDNA) or log2 ratio of masked-nucleotide predictions (GPN)
metric implementation
Pearson correlation per experiment
aggregation
Single CRE
budget
Not reported
protocol id
regulatory-variant-20261009-protocol-tang2025-cagi5-k562

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Zero-shot test
Adaptation
Zero-shot: cosine similarity of embeddings for mutant and wild-type sequence (NT, HyenaDNA) or log2 ratio of masked-nucleotide predictions (GPN)
Scoring implementation
Pearson correlation per experiment

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-10-6e93f504adfc
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
Zero-shot: cosine similarity of embeddings for mutant and wild-type sequence (NT, HyenaDNA) or log2 ratio of masked-nucleotide predictions (GPN)
Context-only references
Evaluating the representational power of pre-trained DNA language models for regulatory genomics

Original source ↗

Table 1 row 'Self-supervised pre-training' / 'GPN (human)', column 'K562'

Version: Genome Biology 26:203, published 2025-07-14; PMC12261763 full-text XML
Retrieved: 2026-10-09T21:04:28Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: f6925cc2d93d0694ccc689970207c2df9b7b0d2562d276ede99f0c78d413b08b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
Single CRE
Context-only references
Evaluating the representational power of pre-trained DNA language models for regulatory genomics

Original source ↗

Table 1 row 'Self-supervised pre-training' / 'GPN (human)', column 'K562'

Version: Genome Biology 26:203, published 2025-07-14; PMC12261763 full-text XML
Retrieved: 2026-10-09T21:04:28Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: f6925cc2d93d0694ccc689970207c2df9b7b0d2562d276ede99f0c78d413b08b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Evaluating the representational power of pre-trained DNA language models for regulatory genomics

Original source ↗

Table 1 row 'Self-supervised pre-training' / 'GPN (human)', column 'K562'

Version: Genome Biology 26:203, published 2025-07-14; PMC12261763 full-text XML
Retrieved: 2026-10-09T21:04:28Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: f6925cc2d93d0694ccc689970207c2df9b7b0d2562d276ede99f0c78d413b08b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
CAGI5 regulation challenge data
Context-only references
Evaluating the representational power of pre-trained DNA language models for regulatory genomics

Original source ↗

Table 1 row 'Self-supervised pre-training' / 'GPN (human)', column 'K562'

Version: Genome Biology 26:203, published 2025-07-14; PMC12261763 full-text XML
Retrieved: 2026-10-09T21:04:28Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: f6925cc2d93d0694ccc689970207c2df9b7b0d2562d276ede99f0c78d413b08b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
230 nt sequence centred on the CRE
Context-only references
Evaluating the representational power of pre-trained DNA language models for regulatory genomics

Original source ↗

Table 1 row 'Self-supervised pre-training' / 'GPN (human)', column 'K562'

Version: Genome Biology 26:203, published 2025-07-14; PMC12261763 full-text XML
Retrieved: 2026-10-09T21:04:28Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: f6925cc2d93d0694ccc689970207c2df9b7b0d2562d276ede99f0c78d413b08b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.metric_implementation
Pearson correlation per experiment
Context-only references
Evaluating the representational power of pre-trained DNA language models for regulatory genomics

Original source ↗

Table 1 row 'Self-supervised pre-training' / 'GPN (human)', column 'K562'

Version: Genome Biology 26:203, published 2025-07-14; PMC12261763 full-text XML
Retrieved: 2026-10-09T21:04:28Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: f6925cc2d93d0694ccc689970207c2df9b7b0d2562d276ede99f0c78d413b08b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.population
PKLR (K562)
Context-only references
Evaluating the representational power of pre-trained DNA language models for regulatory genomics

Original source ↗

Table 1 row 'Self-supervised pre-training' / 'GPN (human)', column 'K562'

Version: Genome Biology 26:203, published 2025-07-14; PMC12261763 full-text XML
Retrieved: 2026-10-09T21:04:28Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: f6925cc2d93d0694ccc689970207c2df9b7b0d2562d276ede99f0c78d413b08b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.protocol_id
regulatory-variant-20261009-protocol-tang2025-cagi5-k562
Context-only references
Evaluating the representational power of pre-trained DNA language models for regulatory genomics

Original source ↗

Table 1 row 'Self-supervised pre-training' / 'GPN (human)', column 'K562'

Version: Genome Biology 26:203, published 2025-07-14; PMC12261763 full-text XML
Retrieved: 2026-10-09T21:04:28Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: f6925cc2d93d0694ccc689970207c2df9b7b0d2562d276ede99f0c78d413b08b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.split
Zero-shot test
Context-only references
Evaluating the representational power of pre-trained DNA language models for regulatory genomics

Original source ↗

Table 1 row 'Self-supervised pre-training' / 'GPN (human)', column 'K562'

Version: Genome Biology 26:203, published 2025-07-14; PMC12261763 full-text XML
Retrieved: 2026-10-09T21:04:28Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: f6925cc2d93d0694ccc689970207c2df9b7b0d2562d276ede99f0c78d413b08b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.origin
independent_paper
Context-only references
Evaluating the representational power of pre-trained DNA language models for regulatory genomics

Original source ↗

Table 1 row 'Self-supervised pre-training' / 'GPN (human)', column 'K562'

Version: Genome Biology 26:203, published 2025-07-14; PMC12261763 full-text XML
Retrieved: 2026-10-09T21:04:28Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.origin

Source artifact SHA-256: f6925cc2d93d0694ccc689970207c2df9b7b0d2562d276ede99f0c78d413b08b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-10-10-6e93f504adfc · Record review: source checked

1 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: regulatory-variant-20261009-eval-tang2025-k562-self-supervised-pre-training-gpn-human

areas
dna-genomes
contexts
research
origin
independent_paper
protocol
regulatory-variant-20261009-protocol-tang2025-cagi5-k562
version
Primary source as retrieved 2026-10-09
comparison
dataset version: CAGI5 regulation challenge data; split: Zero-shot test; population: PKLR (K562); inputs: 230 nt sequence centred on the CRE; adaptation: Zero-shot: cosine similarity of embeddings for mutant and wild-type sequence (NT, HyenaDNA) or log2 ratio of masked-nucleotide predictions (GPN); metric implementation: Pearson correlation per experiment; aggregation: Single CRE; budget: Not reported; protocol id: regulatory-variant-20261009-protocol-tang2025-cagi5-k562
source locator
Table 1 row 'Self-supervised pre-training' / 'GPN (human)', column 'K562'
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