rewirebio.iobenchmarks
Evaluation

KNN_scGPT on Adamson (Csendes et al. 2025)

Published perturbation-response benchmark; transcribed, not reproduced.

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Release 2026-10-10-6e93f504adfc · Evidence verified: Not verified

Evidence incomplete

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Evaluation results

1 evaluation · 6 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: KNN_scGPT (Csendes et al. 2025)Protocol: Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations: unseen-perturbation expression prediction (Csendes et al. 2025 Supplementary Table 2)
Dataset: Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations (GEARS processing, Csendes et al. 2025)
0.994 pearson-correlation
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

KNN_scGPT on Adamson (Csendes et al. 2025)

perturbation-response-20261009-protocol-csendes2025-adamson-pex

Aggregation: Not reported

Csendes et al. 2025, Supplementary Material 4 (Supplementary Tables 1-3) · Supplementary Table 2, cell C13, row 'Adamson / KNN_scGPT', column 'Pearson'
Configuration: KNN_scGPT (Csendes et al. 2025)Protocol: Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations: unseen-perturbation expression prediction (Csendes et al. 2025 Supplementary Table 2)
Dataset: Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations (GEARS processing, Csendes et al. 2025)
0.976 pearson-correlation
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

KNN_scGPT on Adamson (Csendes et al. 2025)

perturbation-response-20261009-protocol-csendes2025-adamson-pex

Aggregation: Not reported

Csendes et al. 2025, Supplementary Material 4 (Supplementary Tables 1-3) · Supplementary Table 2, cell D13, row 'Adamson / KNN_scGPT', column 'Pearson DE'
Configuration: KNN_scGPT (Csendes et al. 2025)Protocol: Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations: unseen-perturbation expression prediction (Csendes et al. 2025 Supplementary Table 2)
Dataset: Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations (GEARS processing, Csendes et al. 2025)
0.753 pearson-delta
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

KNN_scGPT on Adamson (Csendes et al. 2025)

perturbation-response-20261009-protocol-csendes2025-adamson-pex

Aggregation: Not reported

Csendes et al. 2025, Supplementary Material 4 (Supplementary Tables 1-3) · Supplementary Table 2, cell E13, row 'Adamson / KNN_scGPT', column 'Pearson Delta'
Configuration: KNN_scGPT (Csendes et al. 2025)Protocol: Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations: unseen-perturbation expression prediction (Csendes et al. 2025 Supplementary Table 2)
Dataset: Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations (GEARS processing, Csendes et al. 2025)
0.778 pearson-delta
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

KNN_scGPT on Adamson (Csendes et al. 2025)

perturbation-response-20261009-protocol-csendes2025-adamson-pex

Aggregation: Not reported

Csendes et al. 2025, Supplementary Material 4 (Supplementary Tables 1-3) · Supplementary Table 2, cell F13, row 'Adamson / KNN_scGPT', column 'Pearson Delta DE'
Configuration: KNN_scGPT (Csendes et al. 2025)Protocol: Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations: unseen-perturbation expression prediction (Csendes et al. 2025 Supplementary Table 2)
Dataset: Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations (GEARS processing, Csendes et al. 2025)
0.834 pearson-delta
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

KNN_scGPT on Adamson (Csendes et al. 2025)

perturbation-response-20261009-protocol-csendes2025-adamson-pex

Aggregation: Not reported

Csendes et al. 2025, Supplementary Material 4 (Supplementary Tables 1-3) · Supplementary Table 2, cell H13, row 'Adamson / KNN_scGPT', column 'Pearson Delta DE without KOd gene'
Configuration: KNN_scGPT (Csendes et al. 2025)Protocol: Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations: unseen-perturbation expression prediction (Csendes et al. 2025 Supplementary Table 2)
Dataset: Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations (GEARS processing, Csendes et al. 2025)
0.782 pearson-delta
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

KNN_scGPT on Adamson (Csendes et al. 2025)

perturbation-response-20261009-protocol-csendes2025-adamson-pex

Aggregation: Not reported

Csendes et al. 2025, Supplementary Material 4 (Supplementary Tables 1-3) · Supplementary Table 2, cell G13, row 'Adamson / KNN_scGPT', column 'Pearson Delta DE (based on Wilcoxon)'

Source checking is not independent reproduction. Release 2026-10-10-6e93f504adfc.

Evaluation procedure

perturbation-response-20261009-protocol-csendes2025-adamson-pex

Configuration
KNN_scGPT (Csendes et al. 2025)
Protocol
Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations: unseen-perturbation expression prediction (Csendes et al. 2025 Supplementary Table 2)
Dataset
Adamson et al. 2016 Perturb-seq, K562 CRISPRi single perturbations (GEARS processing, Csendes et al. 2025)
origin
Author-reported evaluation
configuration
Primary source as retrieved 2026-10-09
protocol id
perturbation-response-20261009-protocol-csendes2025-adamson-pex
dataset version
cell-gears v0.0.1
split
GEARS perturbation-exclusive split
population
test perturbations (Supplementary Table 1)
inputs
Control cells plus perturbation identity (foundation models); perturbed-gene features (baselines)
adaptation
Fine-tuned or trained per dataset with validation-set selection
metric implementation
Pseudo-bulk Pearson correlations as in the scGPT publication
aggregation
Mean over test perturbations
budget
Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
GEARS perturbation-exclusive split
Adaptation
Fine-tuned or trained per dataset with validation-set selection
Scoring implementation
Pseudo-bulk Pearson correlations as in the scGPT publication

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

38 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-10-6e93f504adfc
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
Fine-tuned or trained per dataset with validation-set selection
Context-only references
Benchmarking foundation cell models for post-perturbation RNA-seq prediction

Original source ↗

Supplementary Table 2 row 13

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: BMC Genomics 26:393, published 2025-04-23; PMC12016270 full-text XML
Retrieved: 2026-10-09T20:58:48Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: b59088e4169385c602d0b7a51253d7c1131688666e64e95c06fb54950a514c19

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.adaptation
Fine-tuned or trained per dataset with validation-set selection
Context-only references
Csendes et al. 2025, Supplementary Material 4 (Supplementary Tables 1-3)

Original source ↗

Supplementary Table 2 row 13

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 12864_2025_11600_MOESM4_ESM.xlsx from the Europe PMC supplementary bundle (hash is of the workbook; the bundle zip is rebuilt per request)
Retrieved: 2026-10-09T20:58:56Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: b5bfcb633921a642de077a39fcb015c6d36bc36a52d9c5e9ceca33be483d3261

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
Mean over test perturbations
Context-only references
Benchmarking foundation cell models for post-perturbation RNA-seq prediction

Original source ↗

Supplementary Table 2 row 13

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: BMC Genomics 26:393, published 2025-04-23; PMC12016270 full-text XML
Retrieved: 2026-10-09T20:58:48Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: b59088e4169385c602d0b7a51253d7c1131688666e64e95c06fb54950a514c19

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
Mean over test perturbations
Context-only references
Csendes et al. 2025, Supplementary Material 4 (Supplementary Tables 1-3)

Original source ↗

Supplementary Table 2 row 13

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 12864_2025_11600_MOESM4_ESM.xlsx from the Europe PMC supplementary bundle (hash is of the workbook; the bundle zip is rebuilt per request)
Retrieved: 2026-10-09T20:58:56Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: b5bfcb633921a642de077a39fcb015c6d36bc36a52d9c5e9ceca33be483d3261

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Benchmarking foundation cell models for post-perturbation RNA-seq prediction

Original source ↗

Supplementary Table 2 row 13

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: BMC Genomics 26:393, published 2025-04-23; PMC12016270 full-text XML
Retrieved: 2026-10-09T20:58:48Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: b59088e4169385c602d0b7a51253d7c1131688666e64e95c06fb54950a514c19

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Csendes et al. 2025, Supplementary Material 4 (Supplementary Tables 1-3)

Original source ↗

Supplementary Table 2 row 13

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 12864_2025_11600_MOESM4_ESM.xlsx from the Europe PMC supplementary bundle (hash is of the workbook; the bundle zip is rebuilt per request)
Retrieved: 2026-10-09T20:58:56Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: b5bfcb633921a642de077a39fcb015c6d36bc36a52d9c5e9ceca33be483d3261

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
cell-gears v0.0.1
Context-only references
Benchmarking foundation cell models for post-perturbation RNA-seq prediction

Original source ↗

Supplementary Table 2 row 13

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: BMC Genomics 26:393, published 2025-04-23; PMC12016270 full-text XML
Retrieved: 2026-10-09T20:58:48Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: b59088e4169385c602d0b7a51253d7c1131688666e64e95c06fb54950a514c19

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
cell-gears v0.0.1
Context-only references
Csendes et al. 2025, Supplementary Material 4 (Supplementary Tables 1-3)

Original source ↗

Supplementary Table 2 row 13

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 12864_2025_11600_MOESM4_ESM.xlsx from the Europe PMC supplementary bundle (hash is of the workbook; the bundle zip is rebuilt per request)
Retrieved: 2026-10-09T20:58:56Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: b5bfcb633921a642de077a39fcb015c6d36bc36a52d9c5e9ceca33be483d3261

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
Control cells plus perturbation identity (foundation models); perturbed-gene features (baselines)
Context-only references
Benchmarking foundation cell models for post-perturbation RNA-seq prediction

Original source ↗

Supplementary Table 2 row 13

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: BMC Genomics 26:393, published 2025-04-23; PMC12016270 full-text XML
Retrieved: 2026-10-09T20:58:48Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: b59088e4169385c602d0b7a51253d7c1131688666e64e95c06fb54950a514c19

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
Control cells plus perturbation identity (foundation models); perturbed-gene features (baselines)
Context-only references
Csendes et al. 2025, Supplementary Material 4 (Supplementary Tables 1-3)

Original source ↗

Supplementary Table 2 row 13

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 12864_2025_11600_MOESM4_ESM.xlsx from the Europe PMC supplementary bundle (hash is of the workbook; the bundle zip is rebuilt per request)
Retrieved: 2026-10-09T20:58:56Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: b5bfcb633921a642de077a39fcb015c6d36bc36a52d9c5e9ceca33be483d3261

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-10-10-6e93f504adfc · Record review: source checked

2 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: perturbation-response-20261009-eval-csendes2025-adamson-knn-scgpt

areas
cells-tissues
contexts
research
origin
author_reported
protocol
perturbation-response-20261009-protocol-csendes2025-adamson-pex
version
Primary source as retrieved 2026-10-09
comparison
protocol id: perturbation-response-20261009-protocol-csendes2025-adamson-pex; dataset version: cell-gears v0.0.1; split: GEARS perturbation-exclusive split; population: test perturbations (Supplementary Table 1); inputs: Control cells plus perturbation identity (foundation models); perturbed-gene features (baselines); adaptation: Fine-tuned or trained per dataset with validation-set selection; metric implementation: Pseudo-bulk Pearson correlations as in the scGPT publication; aggregation: Mean over test perturbations; budget: Not reported
source locator
Supplementary Table 2 row 13
limitations
Baseline constructed by the authors, who conclude that baselines beat the foundation models.
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