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Evaluation

ESM2 OFS pseudo-perplexity: protein variant fitness prediction

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-09-29-06401fd5b220 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

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  • artifact hashes: verification is missing
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  • score semantics: verification is missing
  • metric replay: verification is missing

Verified: Not verified

Evidence incomplete

Investigate discrepancies

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Missing or unresolved evidence

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  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

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Verified: Not verified

Evidence incomplete

Validate independently

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Missing or unresolved evidence

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Verified: Not verified

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Read reviewed discrepancy investigations

Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Pipeline: ESM2 OFS pseudo-perplexityTask: protein variant fitness prediction
Dataset: ProteinGym substitutions
0.403 Spearman rho
unitless · unknown

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

ESM2 OFS pseudo-perplexity: protein variant fitness prediction

authors’ zero-shot ESM2 OFS pseudo-perplexity evaluation; aggregate mean across ProteinGym substitution assays

Aggregation: Not reported

Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation · Published PDF page 6 (033014-6), Table I, ESM2: OFS PP row, Aggregate mean column

Source checking is not independent reproduction. Release 2026-09-29-06401fd5b220.

Evaluation procedure

authors’ zero-shot ESM2 OFS pseudo-perplexity evaluation; aggregate mean across ProteinGym substitution assays

Pipeline
ESM2 OFS pseudo-perplexity
Task
protein variant fitness prediction
Dataset
ProteinGym substitutions
origin
Author-reported evaluation
configuration
not stated in table
protocol id
Not reported
dataset version
Not reported
split
aggregate across assays
population
Not reported
inputs
Not reported
adaptation
Not reported
metric implementation
Not reported
aggregation
Not reported
budget
Not reported

Metadata review: needs review. Unreported conditions prevent automatic comparisons.

Reproduction

Split
aggregate across assays
Adaptation
Not reported
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

17 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-29-06401fd5b220
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
Not reported
Context-only references
Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation

Original source ↗

No field-specific location recorded

Version: PRX Life 2025 journal article
Retrieved: 2026-09-16T10:45:41.099916+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 085ef646f11b8e5335c4b3d86b15fb6c7bf5edf4a80a8b622753ac69d9991a67

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
Not reported
Context-only references
Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation

Original source ↗

No field-specific location recorded

Version: PRX Life 2025 journal article
Retrieved: 2026-09-16T10:45:41.099916+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 085ef646f11b8e5335c4b3d86b15fb6c7bf5edf4a80a8b622753ac69d9991a67

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation

Original source ↗

No field-specific location recorded

Version: PRX Life 2025 journal article
Retrieved: 2026-09-16T10:45:41.099916+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 085ef646f11b8e5335c4b3d86b15fb6c7bf5edf4a80a8b622753ac69d9991a67

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
Not reported
Context-only references
Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation

Original source ↗

No field-specific location recorded

Version: PRX Life 2025 journal article
Retrieved: 2026-09-16T10:45:41.099916+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 085ef646f11b8e5335c4b3d86b15fb6c7bf5edf4a80a8b622753ac69d9991a67

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
Not reported
Context-only references
Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation

Original source ↗

No field-specific location recorded

Version: PRX Life 2025 journal article
Retrieved: 2026-09-16T10:45:41.099916+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 085ef646f11b8e5335c4b3d86b15fb6c7bf5edf4a80a8b622753ac69d9991a67

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.metric_implementation
Not reported
Context-only references
Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation

Original source ↗

No field-specific location recorded

Version: PRX Life 2025 journal article
Retrieved: 2026-09-16T10:45:41.099916+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: 085ef646f11b8e5335c4b3d86b15fb6c7bf5edf4a80a8b622753ac69d9991a67

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.population
Not reported
Context-only references
Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation

Original source ↗

No field-specific location recorded

Version: PRX Life 2025 journal article
Retrieved: 2026-09-16T10:45:41.099916+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: 085ef646f11b8e5335c4b3d86b15fb6c7bf5edf4a80a8b622753ac69d9991a67

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.protocol_id
Not reported
Context-only references
Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation

Original source ↗

No field-specific location recorded

Version: PRX Life 2025 journal article
Retrieved: 2026-09-16T10:45:41.099916+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: 085ef646f11b8e5335c4b3d86b15fb6c7bf5edf4a80a8b622753ac69d9991a67

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.split
aggregate across assays
Context-only references
Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation

Original source ↗

No field-specific location recorded

Version: PRX Life 2025 journal article
Retrieved: 2026-09-16T10:45:41.099916+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: 085ef646f11b8e5335c4b3d86b15fb6c7bf5edf4a80a8b622753ac69d9991a67

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.origin
author_reported
Context-only references
Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation

Original source ↗

No field-specific location recorded

Version: PRX Life 2025 journal article
Retrieved: 2026-09-16T10:45:41.099916+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.origin

Source artifact SHA-256: 085ef646f11b8e5335c4b3d86b15fb6c7bf5edf4a80a8b622753ac69d9991a67

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

View linked audit checks and correction history

Release 2026-09-29-06401fd5b220 · Record review: needs review

1 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: evaluation-b2-esm2-ofs-fitness-2025

areas
proteins-complexes
tasks
protein variant fitness prediction
origin
author_reported
protocol
authors’ zero-shot ESM2 OFS pseudo-perplexity evaluation; aggregate mean across ProteinGym substitution assays
version
not stated in table
comparison
protocol id: Not reported; dataset version: Not reported; split: aggregate across assays; population: Not reported; inputs: Not reported; adaptation: Not reported; metric implementation: Not reported; aggregation: Not reported; budget: Not reported
missing metadata
dataset version: not_reported_in_legacy_extract
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