rewirebio.iobenchmarks
Evaluation

MethAtlas deconvolution, disease detection AUC (liver cancer WGBS)

Published comparison; transcribed, not reproduced.

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Release 2026-10-09-8cc1db47c7f9 · Evidence verified: Not verified

Evidence incomplete

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Verified: Not verified

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Investigate discrepancies

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Verified: Not verified

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Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

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Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: MethAtlas (Sun et al. 2024 benchmark)Protocol: Sun et al. 2024 liver cancer detection from deconvolved plasma WGBS (ROC-AUC)
Dataset: Plasma cfDNA WGBS, 24 liver cancer patients and 32 healthy individuals (EGAD00001000856)
0.91 auroc
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

MethAtlas deconvolution, disease detection AUC (liver cancer WGBS)

ctdnameth-20261009-protocol-sun2024-hcc-wgbs-detection-auc

Aggregation: Not reported

Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA; Sun et al. 2024, Additional file 1 (Tables S1-S8) · Sun Additional file 1, sheet 'Table S7 ', L4; row 'Liver cancer (WGBS)'; column 'MethAtlas' under 'AUC values'

Source checking is not independent reproduction. Release 2026-10-09-8cc1db47c7f9.

Evaluation procedure

ctdnameth-20261009-protocol-sun2024-hcc-wgbs-detection-auc

Configuration
MethAtlas (Sun et al. 2024 benchmark)
Protocol
Sun et al. 2024 liver cancer detection from deconvolved plasma WGBS (ROC-AUC)
Dataset
Plasma cfDNA WGBS, 24 liver cancer patients and 32 healthy individuals (EGAD00001000856)
origin
Independent external evaluation
configuration
Primary source as retrieved 2026-10-09
protocol id
ctdnameth-20261009-protocol-sun2024-hcc-wgbs-detection-auc
dataset version
Reprocessed by Sun et al. 2024 (hg38, Bismark v0.24.2)
split
Not reported
population
24 liver cancer vs 32 healthy, plasma WGBS
inputs
Estimated fractions of 35 reference cell types from each deconvolution method
adaptation
Not reported
metric implementation
Not reported
aggregation
One AUC per cancer-type comparison
budget
Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Not reported
Adaptation
Not reported
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

38 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-09-8cc1db47c7f9
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
Not reported
Context-only references
Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA

Original source ↗

Additional file 1 Table S7, cell L4

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 25:318, published 2024-12-19; PMC11660681.1 full-text XML
Retrieved: 2026-10-09T19:58:16Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: ce2ac8671cfddf088b33efb150ca50354181de81ca6bfb181dd5bf387c6714e8

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.adaptation
Not reported
Context-only references
Sun et al. 2024, Additional file 1 (Tables S1-S8)

Original source ↗

Additional file 1 Table S7, cell L4

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Additional file 1 (13059_2024_3456_MOESM1_ESM.xlsx) of Genome Biology 25:318
Retrieved: 2026-10-09T19:58:22Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 1489ec85628ec60916f2d91faa131fff375436709edb850fee2ef50c860b31b0

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
One AUC per cancer-type comparison
Context-only references
Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA

Original source ↗

Additional file 1 Table S7, cell L4

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 25:318, published 2024-12-19; PMC11660681.1 full-text XML
Retrieved: 2026-10-09T19:58:16Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: ce2ac8671cfddf088b33efb150ca50354181de81ca6bfb181dd5bf387c6714e8

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
One AUC per cancer-type comparison
Context-only references
Sun et al. 2024, Additional file 1 (Tables S1-S8)

Original source ↗

Additional file 1 Table S7, cell L4

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Additional file 1 (13059_2024_3456_MOESM1_ESM.xlsx) of Genome Biology 25:318
Retrieved: 2026-10-09T19:58:22Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 1489ec85628ec60916f2d91faa131fff375436709edb850fee2ef50c860b31b0

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA

Original source ↗

Additional file 1 Table S7, cell L4

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 25:318, published 2024-12-19; PMC11660681.1 full-text XML
Retrieved: 2026-10-09T19:58:16Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: ce2ac8671cfddf088b33efb150ca50354181de81ca6bfb181dd5bf387c6714e8

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Sun et al. 2024, Additional file 1 (Tables S1-S8)

Original source ↗

Additional file 1 Table S7, cell L4

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Additional file 1 (13059_2024_3456_MOESM1_ESM.xlsx) of Genome Biology 25:318
Retrieved: 2026-10-09T19:58:22Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 1489ec85628ec60916f2d91faa131fff375436709edb850fee2ef50c860b31b0

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
Reprocessed by Sun et al. 2024 (hg38, Bismark v0.24.2)
Context-only references
Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA

Original source ↗

Additional file 1 Table S7, cell L4

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 25:318, published 2024-12-19; PMC11660681.1 full-text XML
Retrieved: 2026-10-09T19:58:16Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: ce2ac8671cfddf088b33efb150ca50354181de81ca6bfb181dd5bf387c6714e8

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
Reprocessed by Sun et al. 2024 (hg38, Bismark v0.24.2)
Context-only references
Sun et al. 2024, Additional file 1 (Tables S1-S8)

Original source ↗

Additional file 1 Table S7, cell L4

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Additional file 1 (13059_2024_3456_MOESM1_ESM.xlsx) of Genome Biology 25:318
Retrieved: 2026-10-09T19:58:22Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 1489ec85628ec60916f2d91faa131fff375436709edb850fee2ef50c860b31b0

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
Estimated fractions of 35 reference cell types from each deconvolution method
Context-only references
Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA

Original source ↗

Additional file 1 Table S7, cell L4

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 25:318, published 2024-12-19; PMC11660681.1 full-text XML
Retrieved: 2026-10-09T19:58:16Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: ce2ac8671cfddf088b33efb150ca50354181de81ca6bfb181dd5bf387c6714e8

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
Estimated fractions of 35 reference cell types from each deconvolution method
Context-only references
Sun et al. 2024, Additional file 1 (Tables S1-S8)

Original source ↗

Additional file 1 Table S7, cell L4

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Additional file 1 (13059_2024_3456_MOESM1_ESM.xlsx) of Genome Biology 25:318
Retrieved: 2026-10-09T19:58:22Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 1489ec85628ec60916f2d91faa131fff375436709edb850fee2ef50c860b31b0

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-10-09-8cc1db47c7f9 · Record review: source checked

2 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: ctdnameth-20261009-eval-sun2024-methatlas-hcc-wgbs

areas
dna-genomes
contexts
clinical_research
origin
independent_paper
protocol
ctdnameth-20261009-protocol-sun2024-hcc-wgbs-detection-auc
version
Primary source as retrieved 2026-10-09
comparison
protocol id: ctdnameth-20261009-protocol-sun2024-hcc-wgbs-detection-auc; dataset version: Reprocessed by Sun et al. 2024 (hg38, Bismark v0.24.2); split: Not reported; population: 24 liver cancer vs 32 healthy, plasma WGBS; inputs: Estimated fractions of 35 reference cell types from each deconvolution method; adaptation: Not reported; metric implementation: Not reported; aggregation: One AUC per cancer-type comparison; budget: Not reported
source locator
Additional file 1 Table S7, cell L4
limitations
Random forest validation split not stated; see protocol limitations.
missing metadata
comparison.metric implementation: reason: unreported; comparison.split: reason: unreported
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