rewirebio.iobenchmarks
Evaluation

ichorCNA-TF logistic regression, all tumour fractions

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Release 2026-10-09-ba02f2f4a36e · Evidence verified: Not verified

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Evaluation results

1 evaluation · 16 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.536 accuracy
fraction · higher

Uncertainty: 95% CI 0.531049658385818 to 0.541013108198761. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 50 (feat 'TF', ichorcna_strat 'all', .metric 'test_acc'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.647 accuracy
fraction · higher

Uncertainty: 95% CI 0.642731552938907 to 0.650504861551433. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 51 (feat 'TF', ichorcna_strat 'all', .metric 'test_acc_95spe'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.653 accuracy
fraction · higher

Uncertainty: 95% CI 0.643977997471832 to 0.659762092472169. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 52 (feat 'TF', ichorcna_strat 'all', .metric 'test_acc_98spe'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.634 accuracy
fraction · higher

Uncertainty: 95% CI 0.616718967325738 to 0.650376938481781. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 53 (feat 'TF', ichorcna_strat 'all', .metric 'test_acc_99spe'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.866 auprc
unitless · higher

Uncertainty: 95% CI 0.862608963922692 to 0.869544218585427. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 54 (feat 'TF', ichorcna_strat 'all', .metric 'test_auprc'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.642 auroc
unitless · higher

Uncertainty: 95% CI 0.634830457106185 to 0.649129313044353. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 55 (feat 'TF', ichorcna_strat 'all', .metric 'test_auroc'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.552 f1-score
fraction · higher

Uncertainty: 95% CI 0.544499419390956 to 0.559421831257033. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 56 (feat 'TF', ichorcna_strat 'all', .metric 'test_f1'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.539 f1-score
fraction · higher

Uncertainty: 95% CI 0.529037073340783 to 0.548138880590275. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 57 (feat 'TF', ichorcna_strat 'all', .metric 'test_f1_95spe'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.49 f1-score
fraction · higher

Uncertainty: 95% CI 0.461755353357025 to 0.507804537144719. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 58 (feat 'TF', ichorcna_strat 'all', .metric 'test_f1_98spe'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.418 f1-score
fraction · higher

Uncertainty: 95% CI 0.368437521835668 to 0.464128940675072. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 59 (feat 'TF', ichorcna_strat 'all', .metric 'test_f1_99spe'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.956 precision
fraction · higher

Uncertainty: 95% CI 0.950276128618534 to 0.961981949281337. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 60 (feat 'TF', ichorcna_strat 'all', .metric 'test_ppv'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.374 sensitivity-at-95-percent-specificity
fraction · higher

Uncertainty: 95% CI 0.365694916004718 to 0.382975215973555. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 61 (feat 'TF', ichorcna_strat 'all', .metric 'test_sen_95spe'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.328 sensitivity-at-98-percent-specificity
fraction · higher

Uncertainty: 95% CI 0.310630289471739 to 0.341297092803188. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 62 (feat 'TF', ichorcna_strat 'all', .metric 'test_sen_98spe'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.279 sensitivity-at-99-percent-specificity
fraction · higher

Uncertainty: 95% CI 0.241956979379117 to 0.309680705599319. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 63 (feat 'TF', ichorcna_strat 'all', .metric 'test_sen_99spe'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.389 recall
fraction · higher

Uncertainty: 95% CI 0.381124106659517 to 0.39592438717016. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 64 (feat 'TF', ichorcna_strat 'all', .metric 'test_sensitivity'), column D 'mean'
Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
0.949 specificity
fraction · higher

Uncertainty: 95% CI 0.942030519151722 to 0.956299702195182. Interval over the 50 outer test folds as printed in columns G and H

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

ichorCNA-TF logistic regression, all tumour fractions

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Aggregation: Not reported

A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 65 (feat 'TF', ichorcna_strat 'all', .metric 'test_specificity'), column D 'mean'

Source checking is not independent reproduction. Release 2026-10-09-ba02f2f4a36e.

Evaluation procedure

ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all

Configuration
ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026)
Protocol
UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026)
Dataset
UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples
origin
Independent external evaluation
configuration
Primary source as retrieved 2026-10-09
protocol id
ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all
dataset version
Wang et al. 2026 cross-validation set
split
Nested 5-fold cross-validation, 10 repeats
population
Healthy controls vs cancers with all tumour fractions
inputs
ichorCNA tumour fraction from 0.1x sWGS
adaptation
Model trained per outer fold with inner hyperparameter search
metric implementation
Not reported
aggregation
Mean, median, SD, 95% CI and SEM over 50 outer test folds
budget
Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Nested 5-fold cross-validation, 10 repeats
Adaptation
Model trained per outer fold with inner hyperparameter search
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

38 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-09-ba02f2f4a36e
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
Model trained per outer fold with inner hyperparameter search
Context-only references
A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing

Original source ↗

Data file S2 sheet STATS_lr, rows with feat 'TF' and ichorcna_strat 'all'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Science Advances 12(28):eady9432, published 2026-07-10; PMC13353424 full-text XML
Retrieved: 2026-10-09T20:27:02Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 61464a274501bb9529b2250eb4c112071b8768fa640e87cf13f14d7df9f6fb23

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.adaptation
Model trained per outer fold with inner hyperparameter search
Context-only references
Wang et al. 2026, Data file S2 (model scores and summary statistics)

Original source ↗

Data file S2 sheet STATS_lr, rows with feat 'TF' and ichorcna_strat 'all'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: ady9432_data_file_s2.xlsx inside sciadv.ady9432_data_files_s1_and_s2.zip, PMC open-access copy PMC13353424.1
Retrieved: 2026-10-09T20:23:13Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

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Archive member: ady9432_data_file_s2.xlsx

Inspected artifact

attributes.comparison.aggregation
Mean, median, SD, 95% CI and SEM over 50 outer test folds
Context-only references
A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing

Original source ↗

Data file S2 sheet STATS_lr, rows with feat 'TF' and ichorcna_strat 'all'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Science Advances 12(28):eady9432, published 2026-07-10; PMC13353424 full-text XML
Retrieved: 2026-10-09T20:27:02Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 61464a274501bb9529b2250eb4c112071b8768fa640e87cf13f14d7df9f6fb23

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
Mean, median, SD, 95% CI and SEM over 50 outer test folds
Context-only references
Wang et al. 2026, Data file S2 (model scores and summary statistics)

Original source ↗

Data file S2 sheet STATS_lr, rows with feat 'TF' and ichorcna_strat 'all'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: ady9432_data_file_s2.xlsx inside sciadv.ady9432_data_files_s1_and_s2.zip, PMC open-access copy PMC13353424.1
Retrieved: 2026-10-09T20:23:13Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

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Archive member: ady9432_data_file_s2.xlsx

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing

Original source ↗

Data file S2 sheet STATS_lr, rows with feat 'TF' and ichorcna_strat 'all'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Science Advances 12(28):eady9432, published 2026-07-10; PMC13353424 full-text XML
Retrieved: 2026-10-09T20:27:02Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 61464a274501bb9529b2250eb4c112071b8768fa640e87cf13f14d7df9f6fb23

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Wang et al. 2026, Data file S2 (model scores and summary statistics)

Original source ↗

Data file S2 sheet STATS_lr, rows with feat 'TF' and ichorcna_strat 'all'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: ady9432_data_file_s2.xlsx inside sciadv.ady9432_data_files_s1_and_s2.zip, PMC open-access copy PMC13353424.1
Retrieved: 2026-10-09T20:23:13Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

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Archive member: ady9432_data_file_s2.xlsx

Inspected artifact

attributes.comparison.dataset_version
Wang et al. 2026 cross-validation set
Context-only references
A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing

Original source ↗

Data file S2 sheet STATS_lr, rows with feat 'TF' and ichorcna_strat 'all'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Science Advances 12(28):eady9432, published 2026-07-10; PMC13353424 full-text XML
Retrieved: 2026-10-09T20:27:02Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 61464a274501bb9529b2250eb4c112071b8768fa640e87cf13f14d7df9f6fb23

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
Wang et al. 2026 cross-validation set
Context-only references
Wang et al. 2026, Data file S2 (model scores and summary statistics)

Original source ↗

Data file S2 sheet STATS_lr, rows with feat 'TF' and ichorcna_strat 'all'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: ady9432_data_file_s2.xlsx inside sciadv.ady9432_data_files_s1_and_s2.zip, PMC open-access copy PMC13353424.1
Retrieved: 2026-10-09T20:23:13Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: d28e1dbf64df93fdefd7dd239ab773088b4f27000807c81dd84b0511c64efe12

Hash scope: artifact_sha256 is the zip as served; the member ady9432_data_file_s2.xlsx has SHA-256 32ae4ff3b7e1c85fa8662a57b45f77330e56e475f996f6489f25e36a81de65aa

Archive member: ady9432_data_file_s2.xlsx

Inspected artifact

attributes.comparison.inputs
ichorCNA tumour fraction from 0.1x sWGS
Context-only references
A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing

Original source ↗

Data file S2 sheet STATS_lr, rows with feat 'TF' and ichorcna_strat 'all'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Science Advances 12(28):eady9432, published 2026-07-10; PMC13353424 full-text XML
Retrieved: 2026-10-09T20:27:02Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 61464a274501bb9529b2250eb4c112071b8768fa640e87cf13f14d7df9f6fb23

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
ichorCNA tumour fraction from 0.1x sWGS
Context-only references
Wang et al. 2026, Data file S2 (model scores and summary statistics)

Original source ↗

Data file S2 sheet STATS_lr, rows with feat 'TF' and ichorcna_strat 'all'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: ady9432_data_file_s2.xlsx inside sciadv.ady9432_data_files_s1_and_s2.zip, PMC open-access copy PMC13353424.1
Retrieved: 2026-10-09T20:23:13Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: d28e1dbf64df93fdefd7dd239ab773088b4f27000807c81dd84b0511c64efe12

Hash scope: artifact_sha256 is the zip as served; the member ady9432_data_file_s2.xlsx has SHA-256 32ae4ff3b7e1c85fa8662a57b45f77330e56e475f996f6489f25e36a81de65aa

Archive member: ady9432_data_file_s2.xlsx

Inspected artifact

Sources and history

Release 2026-10-09-ba02f2f4a36e · Record review: source checked

2 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: ctdnafrag-20261009-eval-wang2026-ichorcna-tf-tf-all

areas
dna-genomes
contexts
clinical_research
origin
independent_paper
protocol
ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all
version
Primary source as retrieved 2026-10-09
comparison
protocol id: ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all; dataset version: Wang et al. 2026 cross-validation set; split: Nested 5-fold cross-validation, 10 repeats; population: Healthy controls vs cancers with all tumour fractions; inputs: ichorCNA tumour fraction from 0.1x sWGS; adaptation: Model trained per outer fold with inner hyperparameter search; metric implementation: Not reported; aggregation: Mean, median, SD, 95% CI and SEM over 50 outer test folds; budget: Not reported
source locator
Data file S2 sheet STATS_lr, rows with feat 'TF' and ichorcna_strat 'all'
limitations
Comparator built by the UNITE authors from ichorCNA output; ichorCNA itself was not developed by them.; At 99% specificity, 8 of 50 folds print the constant values (accuracy 0.495, F1 0, sensitivity 0) that mark failed folds elsewhere; the 98% rows have no per-fold values, and Methods P47 names only 95% and 99%.
missing metadata
comparison.metric implementation: reason: unreported; note: Metric code not described beyond the metric names
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