| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.536 accuracy fraction · higher Uncertainty: 95% CI 0.531049658385818 to 0.541013108198761. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 50 (feat 'TF', ichorcna_strat 'all', .metric 'test_acc'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.647 accuracy fraction · higher Uncertainty: 95% CI 0.642731552938907 to 0.650504861551433. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 51 (feat 'TF', ichorcna_strat 'all', .metric 'test_acc_95spe'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.653 accuracy fraction · higher Uncertainty: 95% CI 0.643977997471832 to 0.659762092472169. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 52 (feat 'TF', ichorcna_strat 'all', .metric 'test_acc_98spe'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.634 accuracy fraction · higher Uncertainty: 95% CI 0.616718967325738 to 0.650376938481781. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 53 (feat 'TF', ichorcna_strat 'all', .metric 'test_acc_99spe'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.866 auprc unitless · higher Uncertainty: 95% CI 0.862608963922692 to 0.869544218585427. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 54 (feat 'TF', ichorcna_strat 'all', .metric 'test_auprc'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.642 auroc unitless · higher Uncertainty: 95% CI 0.634830457106185 to 0.649129313044353. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 55 (feat 'TF', ichorcna_strat 'all', .metric 'test_auroc'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.552 f1-score fraction · higher Uncertainty: 95% CI 0.544499419390956 to 0.559421831257033. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 56 (feat 'TF', ichorcna_strat 'all', .metric 'test_f1'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.539 f1-score fraction · higher Uncertainty: 95% CI 0.529037073340783 to 0.548138880590275. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 57 (feat 'TF', ichorcna_strat 'all', .metric 'test_f1_95spe'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.49 f1-score fraction · higher Uncertainty: 95% CI 0.461755353357025 to 0.507804537144719. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 58 (feat 'TF', ichorcna_strat 'all', .metric 'test_f1_98spe'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.418 f1-score fraction · higher Uncertainty: 95% CI 0.368437521835668 to 0.464128940675072. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 59 (feat 'TF', ichorcna_strat 'all', .metric 'test_f1_99spe'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.956 precision fraction · higher Uncertainty: 95% CI 0.950276128618534 to 0.961981949281337. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 60 (feat 'TF', ichorcna_strat 'all', .metric 'test_ppv'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.374 sensitivity-at-95-percent-specificity fraction · higher Uncertainty: 95% CI 0.365694916004718 to 0.382975215973555. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 61 (feat 'TF', ichorcna_strat 'all', .metric 'test_sen_95spe'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.328 sensitivity-at-98-percent-specificity fraction · higher Uncertainty: 95% CI 0.310630289471739 to 0.341297092803188. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 62 (feat 'TF', ichorcna_strat 'all', .metric 'test_sen_98spe'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.279 sensitivity-at-99-percent-specificity fraction · higher Uncertainty: 95% CI 0.241956979379117 to 0.309680705599319. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 63 (feat 'TF', ichorcna_strat 'all', .metric 'test_sen_99spe'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.389 recall fraction · higher Uncertainty: 95% CI 0.381124106659517 to 0.39592438717016. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 64 (feat 'TF', ichorcna_strat 'all', .metric 'test_sensitivity'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with all tumour fractions vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.949 specificity fraction · higher Uncertainty: 95% CI 0.942030519151722 to 0.956299702195182. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, all tumour fractions ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-all Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 65 (feat 'TF', ichorcna_strat 'all', .metric 'test_specificity'), column D 'mean' |
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