rewirebio.iobenchmarks
Evaluation

Geneformer + scFoundation: HLCA to Tabula Sapiens transfer (Wu et al. 2025)

Published annotation transfer benchmark; transcribed, not reproduced.

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-10-10-6e93f504adfc · Evidence verified: Not verified

Evidence incomplete

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Verified: Not verified

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Investigate discrepancies

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  • dependence: verification is missing

Verified: Not verified

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A pinned recipe describes the inputs, environment and resource requirements.

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Verified: Not verified

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Validate independently

Separate data and exposure records support an independent test.

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Evaluation results

1 evaluation · 2 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Ensemble Geneformer + scFoundation (Wu et al. 2025)Protocol: Cross-atlas annotation transfer, HLCA to Tabula Sapiens, 14 shared cell types (Wu et al. 2025 Table S3)
Dataset: Tabula Sapiens (CELLxGENE), 120 leaf cell types after processing
0.816 top-1-accuracy
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer + scFoundation: HLCA to Tabula Sapiens transfer (Wu et al. 2025)

cell-type-20261009-protocol-wu2025-hlca-to-ts

Aggregation: Not reported

Wu et al. 2025, Additional file 3 (Supplementary Tables S1-S13) · Table S3, cell B19, row 'Geneformer + scFoundation', column 'Accuracy@1'
Configuration: Ensemble Geneformer + scFoundation (Wu et al. 2025)Protocol: Cross-atlas annotation transfer, HLCA to Tabula Sapiens, 14 shared cell types (Wu et al. 2025 Table S3)
Dataset: Tabula Sapiens (CELLxGENE), 120 leaf cell types after processing
0.281 macro-f1
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer + scFoundation: HLCA to Tabula Sapiens transfer (Wu et al. 2025)

cell-type-20261009-protocol-wu2025-hlca-to-ts

Aggregation: Not reported

Wu et al. 2025, Additional file 3 (Supplementary Tables S1-S13) · Table S3, cell C19, row 'Geneformer + scFoundation', column 'Macro-F1'

Source checking is not independent reproduction. Release 2026-10-10-6e93f504adfc.

Evaluation procedure

cell-type-20261009-protocol-wu2025-hlca-to-ts

Configuration
Ensemble Geneformer + scFoundation (Wu et al. 2025)
Protocol
Cross-atlas annotation transfer, HLCA to Tabula Sapiens, 14 shared cell types (Wu et al. 2025 Table S3)
Dataset
Tabula Sapiens (CELLxGENE), 120 leaf cell types after processing
origin
Independent external evaluation
configuration
Primary source as retrieved 2026-10-09
protocol id
cell-type-20261009-protocol-wu2025-hlca-to-ts
dataset version
CELLxGENE downloads (Table 2)
split
Reference 20% stratified training split; query all shared-type cells
population
14 shared leaf cell types
inputs
Zero-shot scFM cell embeddings
adaptation
OnClass classifier trained on the reference; scFM frozen
metric implementation
Accuracy@1 and macro-F1 over shared types
aggregation
All query cells of shared types
budget
Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Reference 20% stratified training split; query all shared-type cells
Adaptation
OnClass classifier trained on the reference; scFM frozen
Scoring implementation
Accuracy@1 and macro-F1 over shared types

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

38 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-10-6e93f504adfc
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
OnClass classifier trained on the reference; scFM frozen
Context-only references
Biology-driven insights into the power of single-cell foundation models

Original source ↗

Table S3 row 19; row 'Geneformer + scFoundation'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 26:334, published 2025-10-03; PMC12492631 full-text XML
Retrieved: 2026-10-09T21:22:13Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 368051b7cda5acd4864331875a1faac6f1d68e0a209ed999e4c2ee3b25b57c2c

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.adaptation
OnClass classifier trained on the reference; scFM frozen
Context-only references
Wu et al. 2025, Additional file 3 (Supplementary Tables S1-S13)

Original source ↗

Table S3 row 19; row 'Geneformer + scFoundation'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 13059_2025_3781_MOESM3_ESM.xlsx (38,926 bytes), as linked from the article XML <supplementary-material id="MOESM3">
Retrieved: 2026-10-09T21:22:24Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 51ecea4318178dfb7dc6b51eae23303d68f25e83641809c95429b082353dc99d

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
All query cells of shared types
Context-only references
Biology-driven insights into the power of single-cell foundation models

Original source ↗

Table S3 row 19; row 'Geneformer + scFoundation'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 26:334, published 2025-10-03; PMC12492631 full-text XML
Retrieved: 2026-10-09T21:22:13Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 368051b7cda5acd4864331875a1faac6f1d68e0a209ed999e4c2ee3b25b57c2c

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
All query cells of shared types
Context-only references
Wu et al. 2025, Additional file 3 (Supplementary Tables S1-S13)

Original source ↗

Table S3 row 19; row 'Geneformer + scFoundation'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 13059_2025_3781_MOESM3_ESM.xlsx (38,926 bytes), as linked from the article XML <supplementary-material id="MOESM3">
Retrieved: 2026-10-09T21:22:24Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 51ecea4318178dfb7dc6b51eae23303d68f25e83641809c95429b082353dc99d

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Biology-driven insights into the power of single-cell foundation models

Original source ↗

Table S3 row 19; row 'Geneformer + scFoundation'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 26:334, published 2025-10-03; PMC12492631 full-text XML
Retrieved: 2026-10-09T21:22:13Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 368051b7cda5acd4864331875a1faac6f1d68e0a209ed999e4c2ee3b25b57c2c

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Wu et al. 2025, Additional file 3 (Supplementary Tables S1-S13)

Original source ↗

Table S3 row 19; row 'Geneformer + scFoundation'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 13059_2025_3781_MOESM3_ESM.xlsx (38,926 bytes), as linked from the article XML <supplementary-material id="MOESM3">
Retrieved: 2026-10-09T21:22:24Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 51ecea4318178dfb7dc6b51eae23303d68f25e83641809c95429b082353dc99d

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
CELLxGENE downloads (Table 2)
Context-only references
Biology-driven insights into the power of single-cell foundation models

Original source ↗

Table S3 row 19; row 'Geneformer + scFoundation'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 26:334, published 2025-10-03; PMC12492631 full-text XML
Retrieved: 2026-10-09T21:22:13Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 368051b7cda5acd4864331875a1faac6f1d68e0a209ed999e4c2ee3b25b57c2c

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
CELLxGENE downloads (Table 2)
Context-only references
Wu et al. 2025, Additional file 3 (Supplementary Tables S1-S13)

Original source ↗

Table S3 row 19; row 'Geneformer + scFoundation'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 13059_2025_3781_MOESM3_ESM.xlsx (38,926 bytes), as linked from the article XML <supplementary-material id="MOESM3">
Retrieved: 2026-10-09T21:22:24Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 51ecea4318178dfb7dc6b51eae23303d68f25e83641809c95429b082353dc99d

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
Zero-shot scFM cell embeddings
Context-only references
Biology-driven insights into the power of single-cell foundation models

Original source ↗

Table S3 row 19; row 'Geneformer + scFoundation'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Genome Biology 26:334, published 2025-10-03; PMC12492631 full-text XML
Retrieved: 2026-10-09T21:22:13Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 368051b7cda5acd4864331875a1faac6f1d68e0a209ed999e4c2ee3b25b57c2c

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
Zero-shot scFM cell embeddings
Context-only references
Wu et al. 2025, Additional file 3 (Supplementary Tables S1-S13)

Original source ↗

Table S3 row 19; row 'Geneformer + scFoundation'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 13059_2025_3781_MOESM3_ESM.xlsx (38,926 bytes), as linked from the article XML <supplementary-material id="MOESM3">
Retrieved: 2026-10-09T21:22:24Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 51ecea4318178dfb7dc6b51eae23303d68f25e83641809c95429b082353dc99d

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-10-10-6e93f504adfc · Record review: source checked

2 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: cell-type-20261009-eval-wu2025-hlca-to-ts-ensemble-geneformer-scfoundation

areas
cells-tissues
contexts
research
origin
independent_paper
protocol
cell-type-20261009-protocol-wu2025-hlca-to-ts
version
Primary source as retrieved 2026-10-09
comparison
protocol id: cell-type-20261009-protocol-wu2025-hlca-to-ts; dataset version: CELLxGENE downloads (Table 2); split: Reference 20% stratified training split; query all shared-type cells; population: 14 shared leaf cell types; inputs: Zero-shot scFM cell embeddings; adaptation: OnClass classifier trained on the reference; scFM frozen; metric implementation: Accuracy@1 and macro-F1 over shared types; aggregation: All query cells of shared types; budget: Not reported
source locator
Table S3 row 19; row 'Geneformer + scFoundation'
limitations
The source does not state that any author developed the evaluated scFMs; origin is recorded as independent_paper on that basis.
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