rewirebio.iobenchmarks
Evaluation

NT-v2 paQTL discrimination evaluation

NT-v2 paQTL discrimination evaluation (short window); Feng et al. 2025.

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These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-10-07-1448159e6a81 · Evidence verified: Not verified

Evidence incomplete

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Verified: Not verified

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Investigate discrepancies

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  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

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Run locally

A pinned recipe describes the inputs, environment and resource requirements.

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Verified: Not verified

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Validate independently

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Verified: Not verified

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Read reviewed discrepancy investigations

Evaluation results

1 evaluation · 2 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: NT-v2 (paQTL discrimination)Protocol: Feng paQTL discrimination
Dataset: Feng paQTL discrimination short-window dataset
0.525 paQTL AUC
AUC · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NT-v2 paQTL discrimination evaluation

Table 6, paQTL column, frozen embeddings + random forest classifier

Aggregation: Not reported

Benchmarking DNA foundation models for genomic and genetic tasks · Table 6, AUC block, NT-v2 row, paQTL column (deterministic XML extraction; rowspans resolved per data/omics/amp-coverage-20261007/feng/review-notes.md).
Configuration: NT-v2 (paQTL discrimination)Protocol: Feng paQTL discrimination
Dataset: Feng paQTL discrimination short-window dataset
0.0658 paQTL Cohen’s d
Cohen's d · unknown

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

NT-v2 paQTL discrimination evaluation

Table 6, paQTL column, frozen embeddings + random forest classifier

Aggregation: Not reported

Benchmarking DNA foundation models for genomic and genetic tasks · Table 6, Cohen’s d block, NT-v2 row, paQTL column (deterministic XML extraction; rowspans resolved per data/omics/amp-coverage-20261007/feng/review-notes.md). Signed effect size; no universal desirable sign/direction is stated by the source.

Source checking is not independent reproduction. Release 2026-10-07-1448159e6a81.

Evaluation procedure

Table 6, paQTL column, frozen embeddings + random forest classifier

Configuration
NT-v2 (paQTL discrimination)
Protocol
Feng paQTL discrimination
Dataset
Feng paQTL discrimination short-window dataset
origin
Independent external evaluation
configuration
Not reported
adaptation
Frozen pretrained representation plus a supervised random-forest classifier head fitted for this exact QTL task
aggregation
Mean of AUC/Cohen's d across the three outer chromosome test folds
budget
Not reported
dataset version
Not reported
inputs
Alternate-minus-reference embedding representation around each paQTL variant (short window)
metric implementation
Not reported
population
Borzoi-derived GTEx v8 whole-blood putative causal variants paired with matched noncausal variants by distance to functional site/gene expression. paQTL pre-window-filter positives: 142.
protocol id
amp-feng-20261007-protocol-qtl-paqtl
split
Three disjoint outer chromosome test groups (3/6/9/12/16/18/19/21; 2/5/11/14/17/20/22/X; 1/4/7/8/10/13/15), each held out in turn with fourfold inner-chromosome cross-validation for hyperparameter tuning.

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Three disjoint outer chromosome test groups (3/6/9/12/16/18/19/21; 2/5/11/14/17/20/22/X; 1/4/7/8/10/13/15), each held out in turn with fourfold inner-chromosome cross-validation for hyperparameter tuning.
Adaptation
Frozen pretrained representation plus a supervised random-forest classifier head fitted for this exact QTL task
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

17 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-07-1448159e6a81
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
Frozen pretrained representation plus a supervised random-forest classifier head fitted for this exact QTL task
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.comparison.aggregation
Mean of AUC/Cohen's d across the three outer chromosome test folds
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.comparison.dataset_version
Not reported
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.comparison.inputs
Alternate-minus-reference embedding representation around each paQTL variant (short window)
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.comparison.metric_implementation
Not reported
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.comparison.population
Borzoi-derived GTEx v8 whole-blood putative causal variants paired with matched noncausal variants by distance to functional site/gene expression. paQTL pre-window-filter positives: 142.
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.comparison.protocol_id
amp-feng-20261007-protocol-qtl-paqtl
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.comparison.split
Three disjoint outer chromosome test groups (3/6/9/12/16/18/19/21; 2/5/11/14/17/20/22/X; 1/4/7/8/10/13/15), each held out in turn with fourfold inner-chromosome cross-validation for hyperparameter tuning.
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

attributes.origin
independent_paper
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.origin

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Sources and history

View linked audit checks and correction history

Release 2026-10-07-1448159e6a81 · Record review: source checked

1 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: amp-feng-20261007-eval-qtl-paqtl-nt-v2

comparison
adaptation: Frozen pretrained representation plus a supervised random-forest classifier head fitted for this exact QTL task; aggregation: Mean of AUC/Cohen's d across the three outer chromosome test folds; budget: Not reported; dataset version: Not reported; inputs: Alternate-minus-reference embedding representation around each paQTL variant (short window); metric implementation: Not reported; population: Borzoi-derived GTEx v8 whole-blood putative causal variants paired with matched noncausal variants by distance to functional site/gene expression. paQTL pre-window-filter positives: 142.; protocol id: amp-feng-20261007-protocol-qtl-paqtl; split: Three disjoint outer chromosome test groups (3/6/9/12/16/18/19/21; 2/5/11/14/17/20/22/X; 1/4/7/8/10/13/15), each held out in turn with fourfold inner-chromosome cross-validation for hyperparameter tuning.
missing metadata
budget: Not extracted; no execution
origin
independent_paper
protocol
Table 6, paQTL column, frozen embeddings + random forest classifier
version
Not reported
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