Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture evaluation; bounded primary-source candidate.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture configuration | Protocol: Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture protocol Dataset: Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture dataset | 93.7% positive_percent_agreement_initial_blood_culture percent · higher Uncertainty: 95% CI 84.5–98.2% Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceKarius 2019 plasma microbial cfDNA positive agreement with initial blood culture evaluation amp-20261007-dna-pathogens-protocol Aggregation: Not reported Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture source · Blauwkamp et al. primary article Table 2, PDF page 7, Positive by initial blood culture row: NGS positive 59, NGS negative 4, Agreement 93.7%, 95% CI 84.5–98.2%. Results clinical-validation subsection calls this sensitivity. |
Source checking is not independent reproduction. Release 2026-10-07-1448159e6a81.
amp-20261007-dna-pathogens-protocol
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20 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.comparison.adaptation Not reported Context-only references | Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture source Blauwkamp et al. primary article Table 2, PDF page 7, Positive by initial blood culture row: NGS positive 59, NGS negative 4, Agreement 93.7%, 95% CI 84.5–98.2%. Results clinical-validation subsection calls this sensitivity. Version: Blauwkamp et al., Nature Microbiology 4, 663–674 (2019) | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.comparison.aggregation Not reported Context-only references | Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture source Blauwkamp et al. primary article Table 2, PDF page 7, Positive by initial blood culture row: NGS positive 59, NGS negative 4, Agreement 93.7%, 95% CI 84.5–98.2%. Results clinical-validation subsection calls this sensitivity. Version: Blauwkamp et al., Nature Microbiology 4, 663–674 (2019) | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.comparison.budget Not reported Context-only references | Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture source Blauwkamp et al. primary article Table 2, PDF page 7, Positive by initial blood culture row: NGS positive 59, NGS negative 4, Agreement 93.7%, 95% CI 84.5–98.2%. Results clinical-validation subsection calls this sensitivity. Version: Blauwkamp et al., Nature Microbiology 4, 663–674 (2019) | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.comparison.dataset_version Not reported Context-only references | Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture source Blauwkamp et al. primary article Table 2, PDF page 7, Positive by initial blood culture row: NGS positive 59, NGS negative 4, Agreement 93.7%, 95% CI 84.5–98.2%. Results clinical-validation subsection calls this sensitivity. Version: Blauwkamp et al., Nature Microbiology 4, 663–674 (2019) | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.comparison.inputs Plasma microbial cell-free DNA Context-only references | Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture source Blauwkamp et al. primary article Table 2, PDF page 7, Positive by initial blood culture row: NGS positive 59, NGS negative 4, Agreement 93.7%, 95% CI 84.5–98.2%. Results clinical-validation subsection calls this sensitivity. Version: Blauwkamp et al., Nature Microbiology 4, 663–674 (2019) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.comparison.metric_implementation positive_percent_agreement_initial_blood_culture Context-only references | Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture source Blauwkamp et al. primary article Table 2, PDF page 7, Positive by initial blood culture row: NGS positive 59, NGS negative 4, Agreement 93.7%, 95% CI 84.5–98.2%. Results clinical-validation subsection calls this sensitivity. Version: Blauwkamp et al., Nature Microbiology 4, 663–674 (2019) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.comparison.population SEP-SEQ: 350 prospectively enrolled patients presenting to emergency department with sepsis alert; 348 had both sequencing and initial blood-culture results; initial blood-culture-positive subset n=63. Context-only references | Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture source Blauwkamp et al. primary article Table 2, PDF page 7, Positive by initial blood culture row: NGS positive 59, NGS negative 4, Agreement 93.7%, 95% CI 84.5–98.2%. Results clinical-validation subsection calls this sensitivity. Version: Blauwkamp et al., Nature Microbiology 4, 663–674 (2019) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.comparison.protocol_id amp-20261007-dna-pathogens-protocol Context-only references | Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture source Blauwkamp et al. primary article Table 2, PDF page 7, Positive by initial blood culture row: NGS positive 59, NGS negative 4, Agreement 93.7%, 95% CI 84.5–98.2%. Results clinical-validation subsection calls this sensitivity. Version: Blauwkamp et al., Nature Microbiology 4, 663–674 (2019) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.comparison.split Prospective SEP-SEQ clinical cohort, not a model training/test split Context-only references | Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture source Blauwkamp et al. primary article Table 2, PDF page 7, Positive by initial blood culture row: NGS positive 59, NGS negative 4, Agreement 93.7%, 95% CI 84.5–98.2%. Results clinical-validation subsection calls this sensitivity. Version: Blauwkamp et al., Nature Microbiology 4, 663–674 (2019) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.conventional_baseline Initial blood culture comparator in same 348 paired-result patients. Other conventional microbiological testing and composite adjudication are separate reference standards. Context-only references | Karius 2019 plasma microbial cfDNA positive agreement with initial blood culture source Blauwkamp et al. primary article Table 2, PDF page 7, Positive by initial blood culture row: NGS positive 59, NGS negative 4, Agreement 93.7%, 95% CI 84.5–98.2%. Results clinical-validation subsection calls this sensitivity. Version: Blauwkamp et al., Nature Microbiology 4, 663–674 (2019) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
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Release 2026-10-07-1448159e6a81 · Record review: source checked
Stable ID: amp-20261007-dna-pathogens-evaluation