DELFI 2019 internally cross-validated cancer detection; bounded primary-source candidate.
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1 evaluation · 1 result. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: DELFI 2019 internally cross-validated cancer detection tested configuration | Protocol: DELFI 2019 internally cross-validated cancer detection protocol Dataset: DELFI 2019 internally cross-validated cancer detection cohort | 73% sensitivity_at_reported_98_percent_specificity percent · higher Uncertainty: 95% CI 67%–79%; sensitivity intervals from 2,000 bootstrap replicates Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceDELFI 2019 internally cross-validated cancer detection amp-20261007-ctdna-fragmentomics-protocol Aggregation: Not reported Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 · PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11. |
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amp-20261007-ctdna-fragmentomics-protocol
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20 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.comparison.adaptation Supervised cohort-specific gradient boosting; not a foundation model Context-only references | Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11. Version: Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Format: curator_factual_receipt |
| attributes.comparison.aggregation Not reported Context-only references | Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11. Version: Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Format: curator_factual_receipt |
| attributes.comparison.budget Not reported Context-only references | Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11. Version: Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Format: curator_factual_receipt |
| attributes.comparison.dataset_version Not reported Context-only references | Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11. Version: Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Format: curator_factual_receipt |
| attributes.comparison.inputs Plasma cfDNA whole-genome fragmentation and copy-number features; composite cfDNA includes background and tumour-derived signal Context-only references | Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11. Version: Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Format: curator_factual_receipt |
| attributes.comparison.metric_implementation sensitivity_at_reported_98_percent_specificity Context-only references | Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11. Version: Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Format: curator_factual_receipt |
| attributes.comparison.population 208 patients with seven cancer types and 215 healthy individuals used for classifier; broader study abstract 236 cancers/245 healthy is not classifier denominator. Context-only references | Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11. Version: Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Format: curator_factual_receipt |
| attributes.comparison.protocol_id amp-20261007-ctdna-fragmentomics-protocol Context-only references | Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11. Version: Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Format: curator_factual_receipt |
| attributes.comparison.split 10-fold cross-validation repeated 10 times; feature selection and model estimation on training folds only Context-only references | Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11. Version: Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Format: curator_factual_receipt |
| attributes.conventional_baseline Same Fig. 4/Results P15 feature comparisons: chromosomal-arm copy number ML AUC 0.88, individual copy-number scores AUC 0.78, mitochondrial copy number AUC 0.72; separate ROC endpoints, not sensitivity-matched comparisons. Context-only references | Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11. Version: Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Format: curator_factual_receipt |
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Release 2026-10-07-1448159e6a81 · Record review: source checked
Stable ID: amp-20261007-ctdna-fragmentomics-evaluation