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Evaluation

borzoi-ensemble: multimodal features + LASSO (paper Table 4): Supervised multimodal CAGI5 MPRA prediction

Generate multimodal features using the Borzoi-comparison scoring strategy, standardize from training statistics and fit per-locus LASSO.

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Release 2026-09-29-06401fd5b220 · Evidence verified: Not verified

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Verified: Not verified

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Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

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Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Pipeline: borzoi-ensemble: multimodal features + LASSO (paper Table 4)Protocol: Supervised multimodal CAGI5 MPRA prediction (AlphaGenome paper)
Dataset subset: Supervised multimodal CAGI5 MPRA prediction: evaluated data subset
0.615 Lasso pearsonr (DNASE + RNA + CHIP)
correlation · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

borzoi-ensemble: multimodal features + LASSO (paper Table 4): Supervised multimodal CAGI5 MPRA prediction

Generate multimodal features using the Borzoi-comparison scoring strategy, standardize from training statistics and fit per-locus LASSO.

Aggregation: Mean Pearson correlation across included locus/context tests. The figure-average protocol excludes MYC for LASSO non-convergence and TERT-GBM for matched comparisons.

AlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!L12

Source checking is not independent reproduction. Release 2026-09-29-06401fd5b220.

Evaluation procedure

Generate multimodal features using the Borzoi-comparison scoring strategy, standardize from training statistics and fit per-locus LASSO.

Pipeline
borzoi-ensemble: multimodal features + LASSO (paper Table 4)
Protocol
Supervised multimodal CAGI5 MPRA prediction (AlphaGenome paper)
Dataset subset
Supervised multimodal CAGI5 MPRA prediction: evaluated data subset
origin
Author-reported evaluation
configuration
borzoi-ensemble: multimodal features + LASSO (paper Table 4)
protocol id
alphagenome-2026-t4-protocol-10
dataset version
Not reported
split
Fit feature scaling on challenge training data only; tune a separate LassoCV per locus with10-fold cross-validation, then evaluate the challenge test set.
population
CAGI5 training/test sets per locus, using native hg19 sequence and GENCODEv19.
inputs
Not reported
adaptation
borzoi-ensemble: multimodal features + LASSO (paper Table 4)
metric implementation
Not reported
aggregation
Mean Pearson correlation across included locus/context tests. The figure-average protocol excludes MYC for LASSO non-convergence and TERT-GBM for matched comparisons.
budget
Not reported

Metadata review: needs review. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Fit feature scaling on challenge training data only; tune a separate LassoCV per locus with10-fold cross-validation, then evaluate the challenge test set.
Adaptation
borzoi-ensemble: multimodal features + LASSO (paper Table 4)
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

63 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-29-06401fd5b220
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
borzoi-ensemble: multimodal features + LASSO (paper Table 4)
Context-only references
alphagenome: Journal full-text XML

Original source ↗

No field-specific location recorded

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Retrieved page snapshot; no immutable publisher revision supplied
Retrieved: 2026-09-16T19:53:03.009088+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: d159b791fc6cb7b679c151727b7b05a6e5b6388b08a89b675014983d85b6df36

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

attributes.comparison.adaptation
borzoi-ensemble: multimodal features + LASSO (paper Table 4)
Context-only references
AlphaGenome Nature 2026 supplementary methods

Original source ↗

No field-specific location recorded

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplement to Nature version of record, 28 January 2026; content hash pinned
Retrieved: 2026-09-17T06:37:01.778972+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 86b2e6a07543e3c201e2e157a3e9c6eb5235ff13eb8a5224f6fcb6fe1808d4c0

Hash scope: SHA-256 of exact publisher PDF bytes

Format: original_pdf

Inspected artifact

attributes.comparison.adaptation
borzoi-ensemble: multimodal features + LASSO (paper Table 4)
Context-only references
AlphaGenome Nature 2026 supplementary comparison tables

Original source ↗

No field-specific location recorded

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature version of record, 28 January 2026
Retrieved: 2026-09-17T06:31:06.887921+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154

Hash scope: SHA-256 of exact retrieved original artifact bytes

Format: xlsx

Inspected artifact

attributes.comparison.aggregation
Mean Pearson correlation across included locus/context tests. The figure-average protocol excludes MYC for LASSO non-convergence and TERT-GBM for matched comparisons.
Context-only references
alphagenome: Journal full-text XML

Original source ↗

No field-specific location recorded

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Retrieved page snapshot; no immutable publisher revision supplied
Retrieved: 2026-09-16T19:53:03.009088+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: d159b791fc6cb7b679c151727b7b05a6e5b6388b08a89b675014983d85b6df36

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

attributes.comparison.aggregation
Mean Pearson correlation across included locus/context tests. The figure-average protocol excludes MYC for LASSO non-convergence and TERT-GBM for matched comparisons.
Context-only references
AlphaGenome Nature 2026 supplementary methods

Original source ↗

No field-specific location recorded

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplement to Nature version of record, 28 January 2026; content hash pinned
Retrieved: 2026-09-17T06:37:01.778972+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 86b2e6a07543e3c201e2e157a3e9c6eb5235ff13eb8a5224f6fcb6fe1808d4c0

Hash scope: SHA-256 of exact publisher PDF bytes

Format: original_pdf

Inspected artifact

attributes.comparison.aggregation
Mean Pearson correlation across included locus/context tests. The figure-average protocol excludes MYC for LASSO non-convergence and TERT-GBM for matched comparisons.
Context-only references
AlphaGenome Nature 2026 supplementary comparison tables

Original source ↗

No field-specific location recorded

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature version of record, 28 January 2026
Retrieved: 2026-09-17T06:31:06.887921+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154

Hash scope: SHA-256 of exact retrieved original artifact bytes

Format: xlsx

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
alphagenome: Journal full-text XML

Original source ↗

No field-specific location recorded

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Retrieved page snapshot; no immutable publisher revision supplied
Retrieved: 2026-09-16T19:53:03.009088+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: d159b791fc6cb7b679c151727b7b05a6e5b6388b08a89b675014983d85b6df36

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
AlphaGenome Nature 2026 supplementary methods

Original source ↗

No field-specific location recorded

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplement to Nature version of record, 28 January 2026; content hash pinned
Retrieved: 2026-09-17T06:37:01.778972+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 86b2e6a07543e3c201e2e157a3e9c6eb5235ff13eb8a5224f6fcb6fe1808d4c0

Hash scope: SHA-256 of exact publisher PDF bytes

Format: original_pdf

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
AlphaGenome Nature 2026 supplementary comparison tables

Original source ↗

No field-specific location recorded

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature version of record, 28 January 2026
Retrieved: 2026-09-17T06:31:06.887921+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154

Hash scope: SHA-256 of exact retrieved original artifact bytes

Format: xlsx

Inspected artifact

attributes.comparison.dataset_version
Not reported
Context-only references
alphagenome: Journal full-text XML

Original source ↗

No field-specific location recorded

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Retrieved page snapshot; no immutable publisher revision supplied
Retrieved: 2026-09-16T19:53:03.009088+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: d159b791fc6cb7b679c151727b7b05a6e5b6388b08a89b675014983d85b6df36

Hash scope: SHA-256 of retrieved original artifact bytes

Format: original_artifact

Inspected artifact

Sources and history

View linked audit checks and correction history

Release 2026-09-29-06401fd5b220 · Record review: needs review

3 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: alphagenome-2026-evaluation-10258803d6641706

areas
dna-genomes
origin
author_reported
protocol
Generate multimodal features using the Borzoi-comparison scoring strategy, standardize from training statistics and fit per-locus LASSO.
version
borzoi-ensemble: multimodal features + LASSO (paper Table 4)
source evaluation index
10
source table
4
comparison
protocol id: alphagenome-2026-t4-protocol-10; dataset version: Not reported; split: Fit feature scaling on challenge training data only; tune a separate LassoCV per locus with10-fold cross-validation, then evaluate the challenge test set.; population: CAGI5 training/test sets per locus, using native hg19 sequence and GENCODEv19.; inputs: Not reported; adaptation: borzoi-ensemble: multimodal features + LASSO (paper Table 4); metric implementation: Not reported; aggregation: Mean Pearson correlation across included locus/context tests. The figure-average protocol excludes MYC for LASSO non-convergence and TERT-GBM for matched comparisons.; budget: Not reported
context
allowed inputs: DNase, histone ChIP-seq and target-gene RNA variant-score features across available cell types.; limitations: This is supervised pipeline performance, not a zero-shot base-model result. The F9 exclusion described for DNase-only LASSO must not be automatically applied to this multimodal row.
missing metadata
dataset version: unextracted; exact input manifest: unextracted; inference budget: unreported; scoring failures: unreported
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