rewirebio.iobenchmarks
Dataset

OncoKB actionable-genes table, 625 variant-cancer-drug associations (accessed 2024-11-20)

OncoKB levels of evidence used as the reference labels by Lin et al. 2025.

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-10-09-ba02f2f4a36e · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • recipe pinned: verification is missing
  • resource estimate: verification is missing

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • independent validation: verification is missing
  • overlap checked: verification is missing

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Read reviewed discrepancy investigations

Evaluation results

6 evaluations · 6 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: GPT-4o, basic prompt, temperature 1.0 (default) (Lin et al. 2025)Protocol: Lin et al. 2025 OncoKB level-of-evidence assignment
Dataset: OncoKB actionable-genes table, 625 variant-cancer-drug associations (accessed 2024-11-20)
0.339 top-1-accuracy
fraction · higher

Uncertainty: 95% CI 0.3369 to 0.3417

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

gpt-4o-basic on oncokb (Lin et al. 2025)

egfrnsclc-20261009-protocol-lin2025-oncokb-level-assignment

Aggregation: Not reported

Benchmarking large language models GPT-4o, llama 3.1, and qwen 2.5 for cancer genetic variant classification · Table 1 (Tab1), row 'OncoKB', column 'GPT-4o' Mean accuracy; 95% CI in the next column
Configuration: Llama 3.1 70B, basic prompt, temperature 0.4 (Lin et al. 2025)Protocol: Lin et al. 2025 OncoKB level-of-evidence assignment
Dataset: OncoKB actionable-genes table, 625 variant-cancer-drug associations (accessed 2024-11-20)
0.318 top-1-accuracy
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

llama-basic-t0-4 on oncokb (Lin et al. 2025)

egfrnsclc-20261009-protocol-lin2025-oncokb-level-assignment

Aggregation: Not reported

Benchmarking large language models GPT-4o, llama 3.1, and qwen 2.5 for cancer genetic variant classification · Table 2 (Tab2), row 10 ('Llama 3.1', 'Basic prompt + temperature (0.4)', 'OncoKB'), column 'Accuracy'
Configuration: Llama 3.1 70B, basic prompt, temperature 0.8 (default) (Lin et al. 2025)Protocol: Lin et al. 2025 OncoKB level-of-evidence assignment
Dataset: OncoKB actionable-genes table, 625 variant-cancer-drug associations (accessed 2024-11-20)
0.307 top-1-accuracy
fraction · higher

Uncertainty: 95% CI 0.3041 to 0.309

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

llama-basic-t0-8 on oncokb (Lin et al. 2025)

egfrnsclc-20261009-protocol-lin2025-oncokb-level-assignment

Aggregation: Not reported

Benchmarking large language models GPT-4o, llama 3.1, and qwen 2.5 for cancer genetic variant classification · Table 1 (Tab1), row 'OncoKB', column 'Llama 3' Mean accuracy; 95% CI in the next column
Configuration: Llama 3.1 70B, basic prompt, temperature 0 (Lin et al. 2025)Protocol: Lin et al. 2025 OncoKB level-of-evidence assignment
Dataset: OncoKB actionable-genes table, 625 variant-cancer-drug associations (accessed 2024-11-20)
0.331 top-1-accuracy
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

llama-basic-t0 on oncokb (Lin et al. 2025)

egfrnsclc-20261009-protocol-lin2025-oncokb-level-assignment

Aggregation: Not reported

Benchmarking large language models GPT-4o, llama 3.1, and qwen 2.5 for cancer genetic variant classification · Table 2 (Tab2), row 11 ('Llama 3.1', 'Basic prompt + temperature (0)', 'OncoKB'), column 'Accuracy'
Configuration: Qwen 2.5 72B, basic prompt, temperature 0.8 (default) (Lin et al. 2025)Protocol: Lin et al. 2025 OncoKB level-of-evidence assignment
Dataset: OncoKB actionable-genes table, 625 variant-cancer-drug associations (accessed 2024-11-20)
0.333 top-1-accuracy
fraction · higher

Uncertainty: 95% CI 0.3316 to 0.334

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

qwen-basic on oncokb (Lin et al. 2025)

egfrnsclc-20261009-protocol-lin2025-oncokb-level-assignment

Aggregation: Not reported

Benchmarking large language models GPT-4o, llama 3.1, and qwen 2.5 for cancer genetic variant classification · Table 1 (Tab1), row 'OncoKB', column 'Qwen 2.5' Mean accuracy; 95% CI in the next column
Configuration: Qwen 2.5 72B, refined prompt, temperature 0.8 (default) (Lin et al. 2025)Protocol: Lin et al. 2025 OncoKB level-of-evidence assignment
Dataset: OncoKB actionable-genes table, 625 variant-cancer-drug associations (accessed 2024-11-20)
0.299 top-1-accuracy
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

qwen-refined on oncokb (Lin et al. 2025)

egfrnsclc-20261009-protocol-lin2025-oncokb-level-assignment

Aggregation: Not reported

Benchmarking large language models GPT-4o, llama 3.1, and qwen 2.5 for cancer genetic variant classification · Table 2 (Tab2), row 6 ('Qwen2.5', 'Refined prompt + Default temperature (0.8)', 'OncoKB'), column 'Accuracy'

Source checking is not independent reproduction. Release 2026-10-09-ba02f2f4a36e.

Dataset and evaluation context

A dataset supplies biological observations. The evaluation protocol defines how those observations are split, used and scored.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

7 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-09-ba02f2f4a36e
Property and statementOriginal source and locationReview and provenance
attributes.access
Downloaded by the authors from https://www.oncokb.org/actionable-genes (Methods P36); the table itself is not copied into this batch
Context-only references
Benchmarking large language models GPT-4o, llama 3.1, and qwen 2.5 for cancer genetic variant classification

Original source ↗

Lin et al. 2025 Methods P36

Version: npj Precision Oncology 9:141, published 2025-05-15; PMC12078457 full-text XML
Retrieved: 2026-10-09T20:43:36Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.access

Source artifact SHA-256: 09c67fcaf7b367d74500db5fd015968389371dcb9ee5a37ccc83241aa63c0f80

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.population
625 associations: Level 1 182, Level 2 154, Level 3 114, Level 4 80, R1 34, R2 61
Context-only references
Benchmarking large language models GPT-4o, llama 3.1, and qwen 2.5 for cancer genetic variant classification

Original source ↗

Lin et al. 2025 Methods P36

Version: npj Precision Oncology 9:141, published 2025-05-15; PMC12078457 full-text XML
Retrieved: 2026-10-09T20:43:36Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population

Source artifact SHA-256: 09c67fcaf7b367d74500db5fd015968389371dcb9ee5a37ccc83241aa63c0f80

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.source_locator
Lin et al. 2025 Methods P36
Context-only references
Benchmarking large language models GPT-4o, llama 3.1, and qwen 2.5 for cancer genetic variant classification

Original source ↗

Lin et al. 2025 Methods P36

Version: npj Precision Oncology 9:141, published 2025-05-15; PMC12078457 full-text XML
Retrieved: 2026-10-09T20:43:36Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.source_locator

Source artifact SHA-256: 09c67fcaf7b367d74500db5fd015968389371dcb9ee5a37ccc83241aa63c0f80

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.total
625
Context-only references
Benchmarking large language models GPT-4o, llama 3.1, and qwen 2.5 for cancer genetic variant classification

Original source ↗

Lin et al. 2025 Methods P36

Version: npj Precision Oncology 9:141, published 2025-05-15; PMC12078457 full-text XML
Retrieved: 2026-10-09T20:43:36Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.total

Source artifact SHA-256: 09c67fcaf7b367d74500db5fd015968389371dcb9ee5a37ccc83241aa63c0f80

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.version
OncoKB actionable genes table, last accessed 2024-11-20
Context-only references
Benchmarking large language models GPT-4o, llama 3.1, and qwen 2.5 for cancer genetic variant classification

Original source ↗

Lin et al. 2025 Methods P36

Version: npj Precision Oncology 9:141, published 2025-05-15; PMC12078457 full-text XML
Retrieved: 2026-10-09T20:43:36Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.version

Source artifact SHA-256: 09c67fcaf7b367d74500db5fd015968389371dcb9ee5a37ccc83241aa63c0f80

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

description
OncoKB levels of evidence used as the reference labels by Lin et al. 2025.
Context-only references
Benchmarking large language models GPT-4o, llama 3.1, and qwen 2.5 for cancer genetic variant classification

Original source ↗

Lin et al. 2025 Methods P36

Version: npj Precision Oncology 9:141, published 2025-05-15; PMC12078457 full-text XML
Retrieved: 2026-10-09T20:43:36Z

not individually reviewed

No individual claim review recorded

Audit details

Field: description

Source artifact SHA-256: 09c67fcaf7b367d74500db5fd015968389371dcb9ee5a37ccc83241aa63c0f80

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

name
OncoKB actionable-genes table, 625 variant-cancer-drug associations (accessed 2024-11-20)
Context-only references
Benchmarking large language models GPT-4o, llama 3.1, and qwen 2.5 for cancer genetic variant classification

Original source ↗

Lin et al. 2025 Methods P36

Version: npj Precision Oncology 9:141, published 2025-05-15; PMC12078457 full-text XML
Retrieved: 2026-10-09T20:43:36Z

not individually reviewed

No individual claim review recorded

Audit details

Field: name

Source artifact SHA-256: 09c67fcaf7b367d74500db5fd015968389371dcb9ee5a37ccc83241aa63c0f80

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-10-09-ba02f2f4a36e · Record review: source checked

1 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: egfrnsclc-20261009-data-lin2025-oncokb-associations

areas
dna-genomes
contexts
clinical_research
version
OncoKB actionable genes table, last accessed 2024-11-20
total
625
population
625 associations: Level 1 182, Level 2 154, Level 3 114, Level 4 80, R1 34, R2 61
access
Downloaded by the authors from https://www.oncokb.org/actionable-genes (Methods P36); the table itself is not copied into this batch
source locator
Lin et al. 2025 Methods P36
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