Evidence claim

Relevance of TraitGym Complex traits, zero-shot, AUPRC by chromosome weighted average to "Select regulatory variants and genes for functional follow-up"

Use case: Select regulatory variants and genes for functional follow-up
Assessed by: TraitGym Complex traits, zero-shot, AUPRC by chromosome weighted average
Relevance: Proxy evidence
Endpoint: AUPRC (per-chromosome weighted average, with bootstrap SE) of zero-shot scores from gLMs, sequence-to-function models, CADD and conservation for Complex traits causal versus matched noncoding variants

TraitGym Complex traits zero-shot AUPRC as evidence for choosing causal noncoding variants to follow up.

57 reviewed evaluations

Evidence

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Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

19 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Citation locations 1 values source id lit-genomics-20261011-traitgym-source-hf-metrics locator complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/ Context-only references	TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) Original source ↗ lit-genomics-20261011-traitgym-source-hf-metrics: complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/ Version: Hugging Face dataset revision 1fde19555fe8c0a55b1382bdf4c6f7082209f566 (last modified 2025-03-25); 156 metric CSVs under {dataset}/AUPRC_by_chrom_weighted_average/all/ Retrieved: 2026-10-11T01:40:33Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.citation_locators` Source artifact SHA-256: `44dfedc00ac5c7918b188af2a5a200f08da3b641f73d7d5327e26f94a7d0372e` Hash scope: SHA-256 of a JSON bundle listing every retrieved CSV with its path, its own SHA-256 and its bytes (artifacts/traitgym-metrics-bundle.json.gz) Inspected artifact
Comparison group traitgym-official Context-only references	TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) Original source ↗ lit-genomics-20261011-traitgym-source-hf-metrics: complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/ Version: Hugging Face dataset revision 1fde19555fe8c0a55b1382bdf4c6f7082209f566 (last modified 2025-03-25); 156 metric CSVs under {dataset}/AUPRC_by_chrom_weighted_average/all/ Retrieved: 2026-10-11T01:40:33Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.comparison_group` Source artifact SHA-256: `44dfedc00ac5c7918b188af2a5a200f08da3b641f73d7d5327e26f94a7d0372e` Hash scope: SHA-256 of a JSON bundle listing every retrieved CSV with its path, its own SHA-256 and its bytes (artifacts/traitgym-metrics-bundle.json.gz) Inspected artifact
Comparison title TraitGym official metrics Context-only references	TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) Original source ↗ lit-genomics-20261011-traitgym-source-hf-metrics: complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/ Version: Hugging Face dataset revision 1fde19555fe8c0a55b1382bdf4c6f7082209f566 (last modified 2025-03-25); 156 metric CSVs under {dataset}/AUPRC_by_chrom_weighted_average/all/ Retrieved: 2026-10-11T01:40:33Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.comparison_title` Source artifact SHA-256: `44dfedc00ac5c7918b188af2a5a200f08da3b641f73d7d5327e26f94a7d0372e` Hash scope: SHA-256 of a JSON bundle listing every retrieved CSV with its path, its own SHA-256 and its bytes (artifacts/traitgym-metrics-bundle.json.gz) Inspected artifact
Constraints 3 values Inspect every linked evaluation's source locator before citing a result. Do not combine this mapping's evaluations with any other protocol's results. Compare only within the same dataset and mode; the baseline AUPRC is 0.1. Context-only references	TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) Original source ↗ lit-genomics-20261011-traitgym-source-hf-metrics: complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/ Version: Hugging Face dataset revision 1fde19555fe8c0a55b1382bdf4c6f7082209f566 (last modified 2025-03-25); 156 metric CSVs under {dataset}/AUPRC_by_chrom_weighted_average/all/ Retrieved: 2026-10-11T01:40:33Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.constraints` Source artifact SHA-256: `44dfedc00ac5c7918b188af2a5a200f08da3b641f73d7d5327e26f94a7d0372e` Hash scope: SHA-256 of a JSON bundle listing every retrieved CSV with its path, its own SHA-256 and its bytes (artifacts/traitgym-metrics-bundle.json.gz) Inspected artifact
Endpoint AUPRC (per-chromosome weighted average, with bootstrap SE) of zero-shot scores from gLMs, sequence-to-function models, CADD and conservation for Complex traits causal versus matched noncoding variants Context-only references	TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) Original source ↗ lit-genomics-20261011-traitgym-source-hf-metrics: complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/ Version: Hugging Face dataset revision 1fde19555fe8c0a55b1382bdf4c6f7082209f566 (last modified 2025-03-25); 156 metric CSVs under {dataset}/AUPRC_by_chrom_weighted_average/all/ Retrieved: 2026-10-11T01:40:33Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.endpoint` Source artifact SHA-256: `44dfedc00ac5c7918b188af2a5a200f08da3b641f73d7d5327e26f94a7d0372e` Hash scope: SHA-256 of a JSON bundle listing every retrieved CSV with its path, its own SHA-256 and its bytes (artifacts/traitgym-metrics-bundle.json.gz) Inspected artifact
Claimed field links:assessed_by:lit-genomics-20261011-traitgym-protocol-complex-traits-matched-9-zero-shot Context-only references	TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) Original source ↗ lit-genomics-20261011-traitgym-source-hf-metrics: complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/ Version: Hugging Face dataset revision 1fde19555fe8c0a55b1382bdf4c6f7082209f566 (last modified 2025-03-25); 156 metric CSVs under {dataset}/AUPRC_by_chrom_weighted_average/all/ Retrieved: 2026-10-11T01:40:33Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.field` Source artifact SHA-256: `44dfedc00ac5c7918b188af2a5a200f08da3b641f73d7d5327e26f94a7d0372e` Hash scope: SHA-256 of a JSON bundle listing every retrieved CSV with its path, its own SHA-256 and its bytes (artifacts/traitgym-metrics-bundle.json.gz) Inspected artifact
Headline metric auprc Context-only references	TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) Original source ↗ lit-genomics-20261011-traitgym-source-hf-metrics: complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/ Version: Hugging Face dataset revision 1fde19555fe8c0a55b1382bdf4c6f7082209f566 (last modified 2025-03-25); 156 metric CSVs under {dataset}/AUPRC_by_chrom_weighted_average/all/ Retrieved: 2026-10-11T01:40:33Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.headline_metric` Source artifact SHA-256: `44dfedc00ac5c7918b188af2a5a200f08da3b641f73d7d5327e26f94a7d0372e` Hash scope: SHA-256 of a JSON bundle listing every retrieved CSV with its path, its own SHA-256 and its bytes (artifacts/traitgym-metrics-bundle.json.gz) Inspected artifact
Limitations 4 values Benchmark authors developed GPN-MSA and GPN-Promoter (author_reported). Complex-trait positives come from UK Biobank fine-mapping (high posterior inclusion probability, mostly European ancestry). Labels are not experimental allele effects. Official metrics files on a mutable Hugging Face dataset, pinned by revision. Context-only references	TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) Original source ↗ lit-genomics-20261011-traitgym-source-hf-metrics: complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/ Version: Hugging Face dataset revision 1fde19555fe8c0a55b1382bdf4c6f7082209f566 (last modified 2025-03-25); 156 metric CSVs under {dataset}/AUPRC_by_chrom_weighted_average/all/ Retrieved: 2026-10-11T01:40:33Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.limitations` Source artifact SHA-256: `44dfedc00ac5c7918b188af2a5a200f08da3b641f73d7d5327e26f94a7d0372e` Hash scope: SHA-256 of a JSON bundle listing every retrieved CSV with its path, its own SHA-256 and its bytes (artifacts/traitgym-metrics-bundle.json.gz) Inspected artifact
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attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 9e4f44a16657a77c3629b6dc730c1f2e87df26c00833e2c62499cfb3a0226ccc record id lit-genomics-20261011-traitgym-result-specieslm-llr-minus-score-complex-traits-matched-9 fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 56a106c614896209bfb6acb205ac70e33152536b01ab3d67e20f979f61348a82 record id lit-genomics-20261011-traitgym-source-hf-metrics fields status attributes.artifact_sha256 sha256 865b9568f1a674d20cfecf890361ad3606fcb35a0932b64fbe70ff045e727a59 record id use-case-regulatory-variant-gene-follow-up fields status name description facets attributes.question attributes.decision attributes.inputs attributes.output attributes.exclusions attributes.setting attributes.clinical_scope attributes.intended_users sha256 0071547e01ccaec30238aea9e4882dd92e6f51be9c967c7fb88bc61d2788b870 Context-only references	TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) Original source ↗ lit-genomics-20261011-traitgym-source-hf-metrics: complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/ Version: Hugging Face dataset revision 1fde19555fe8c0a55b1382bdf4c6f7082209f566 (last modified 2025-03-25); 156 metric CSVs under {dataset}/AUPRC_by_chrom_weighted_average/all/ Retrieved: 2026-10-11T01:40:33Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.pins` Source artifact SHA-256: `44dfedc00ac5c7918b188af2a5a200f08da3b641f73d7d5327e26f94a7d0372e` Hash scope: SHA-256 of a JSON bundle listing every retrieved CSV with its path, its own SHA-256 and its bytes (artifacts/traitgym-metrics-bundle.json.gz) Inspected artifact
Rationale Proxy, not direct: the inputs match fine-mapped or curated candidate variants at a locus, but the output only ranks variants; it gives no element-gene link and no effect direction, which the use case needs to design perturbations. Context-only references	TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) Original source ↗ lit-genomics-20261011-traitgym-source-hf-metrics: complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/ Version: Hugging Face dataset revision 1fde19555fe8c0a55b1382bdf4c6f7082209f566 (last modified 2025-03-25); 156 metric CSVs under {dataset}/AUPRC_by_chrom_weighted_average/all/ Retrieved: 2026-10-11T01:40:33Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.rationale` Source artifact SHA-256: `44dfedc00ac5c7918b188af2a5a200f08da3b641f73d7d5327e26f94a7d0372e` Hash scope: SHA-256 of a JSON bundle listing every retrieved CSV with its path, its own SHA-256 and its bytes (artifacts/traitgym-metrics-bundle.json.gz) Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) · Original source · Hugging Face dataset revision 1fde19555fe8c0a55b1382bdf4c6f7082209f566 (last modified 2025-03-25); 156 metric CSVs under {dataset}/AUPRC_by_chrom_weighted_average/all/

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Technical metadata and extraction receipts

Stable ID: use-case-mapping-lit-genomics-20261011-traitgym-complex-traits-matched-9-zero-shot

field: links:assessed_by:lit-genomics-20261011-traitgym-protocol-complex-traits-matched-9-zero-shot
value: lit-genomics-20261011-traitgym-protocol-complex-traits-matched-9-zero-shot
relevance: proxy
endpoint: AUPRC (per-chromosome weighted average, with bootstrap SE) of zero-shot scores from gLMs, sequence-to-function models, CADD and conservation for Complex traits causal versus matched noncoding variants
rationale: Proxy, not direct: the inputs match fine-mapped or curated candidate variants at a locus, but the output only ranks variants; it gives no element-gene link and no effect direction, which the use case needs to design perturbations.
constraints: Inspect every linked evaluation's source locator before citing a result.; Do not combine this mapping's evaluations with any other protocol's results.; Compare only within the same dataset and mode; the baseline AUPRC is 0.1.
limitations: Benchmark authors developed GPN-MSA and GPN-Promoter (author_reported).; Complex-trait positives come from UK Biobank fine-mapping (high posterior inclusion probability, mostly European ancestry).; Labels are not experimental allele effects.; Official metrics files on a mutable Hugging Face dataset, pinned by revision.
citation locators: source id: lit-genomics-20261011-traitgym-source-hf-metrics; locator: complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/
source locator: lit-genomics-20261011-traitgym-source-hf-metrics: complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/
headline metric: auprc
reason: Add a relevance judgement for a genomic foundation model benchmark protocol from the 2026-10-11 genomics suite pass, reviewed in docs/reviews/2026-10-11-genomics-gfm-suites.md.
comparison group: traitgym-official
comparison title: TraitGym official metrics
stratum label: Complex traits, zero-shot
stratum order: 3
reviewed evaluations: lit-genomics-20261011-traitgym-eval-aido-dna-absllr-plus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-aido-dna-embeddings-minus-inner-product-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-aido-dna-embeddings-plus-cosine-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-aido-dna-embeddings-plus-euclidean-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-aido-dna-llr-minus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-borzoi-l2-l2-plus-all-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-cadd-plus-rawscore-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-caduceus-absllr-plus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-caduceus-embeddings-minus-inner-product-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-caduceus-embeddings-plus-cosine-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-caduceus-embeddings-plus-euclidean-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-caduceus-llr-minus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-enformer-l2-l2-plus-all-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-1b-base-absllr-plus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-1b-base-embeddings-minus-inner-product-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-1b-base-embeddings-plus-cosine-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-1b-base-embeddings-plus-euclidean-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-1b-base-llr-minus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-40b-absllr-plus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-40b-embeddings-minus-inner-product-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-40b-embeddings-plus-cosine-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-40b-embeddings-plus-euclidean-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-40b-llr-minus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-7b-absllr-plus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-7b-embeddings-minus-inner-product-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-7b-embeddings-plus-cosine-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-7b-embeddings-plus-euclidean-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-evo2-7b-llr-minus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-gpn-final-absllr-plus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-gpn-final-embeddings-minus-inner-product-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-gpn-final-embeddings-plus-cosine-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-gpn-final-embeddings-plus-euclidean-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-gpn-final-llr-minus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-gpn-msa-absllr-plus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-gpn-msa-embeddings-minus-inner-product-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-gpn-msa-embeddings-plus-cosine-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-gpn-msa-embeddings-plus-euclidean-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-gpn-msa-llr-minus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-hyenadna-absllr-plus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-hyenadna-embeddings-minus-inner-product-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-hyenadna-embeddings-plus-cosine-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-hyenadna-embeddings-plus-euclidean-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-hyenadna-llr-minus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-nucleotidetransformer-absllr-plus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-nucleotidetransformer-embeddings-minus-inner-product-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-nucleotidetransformer-embeddings-plus-cosine-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-nucleotidetransformer-embeddings-plus-euclidean-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-nucleotidetransformer-llr-minus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-phastcons-43p-plus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-phylop-100v-plus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-phylop-241m-plus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-sei-plus-seqclass-max-absdiff-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-specieslm-absllr-plus-score-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-specieslm-embeddings-minus-inner-product-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-specieslm-embeddings-plus-cosine-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-specieslm-embeddings-plus-euclidean-distance-complex-traits-matched-9; lit-genomics-20261011-traitgym-eval-specieslm-llr-minus-score-complex-traits-matched-9
review: method: ai-assisted-source-review; scope-review; method note: Reviewer checked the endpoint against the use case's inputs and output, the proxy rating and the limitations; every evaluation on the protocol had its values checked in the batch review. Corrections listed in review.md were applied by the extractor.; reviewer: claude; reviewer note: Claude review agent reviewer-gen-3, independent of the extractor lit-genomics; no human review claimed; reviewed at: 2026-10-11T14:40:00Z; note: Automated review; not human scientific review.
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