selection_bias: rna-splicing-20261009-data-drost2025-inhouse-subset
Descriptive fact transcribed from the pinned source.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
12 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.field selection_bias Context-only references | Routine RNA-based analysis of potential splicing variants facilitates genomic diagnostics and reveals limitations of in silico prediction tools Results 'RNA splicing analysis reclassifies 54% of VUS' paragraph 1 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: HGG Advances 7(1):100521, published online 2025-09-22; PMC12547740 full-text XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.field selection_bias Context-only references | Drost et al. 2025, Data S1 (Tables S1-S6) Results 'RNA splicing analysis reclassifies 54% of VUS' paragraph 1 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: mmc2.xlsx (Data S1. Tables S1-S6) inside the Europe PMC supplementaryFiles zip for PMC12547740 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of mmc2.xlsx as extracted from the supplementaryFiles zip (zip SHA-256 1c89a7ebc0bf686c6087d0fee86ba6f364a6d754d5bc7eb9c446b7db017f1ebc; the zip is re-built by Europe PMC on each request, so only the member hash is stable). |
| attributes.source_locator Results 'RNA splicing analysis reclassifies 54% of VUS' paragraph 1 Context-only references | Routine RNA-based analysis of potential splicing variants facilitates genomic diagnostics and reveals limitations of in silico prediction tools Results 'RNA splicing analysis reclassifies 54% of VUS' paragraph 1 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: HGG Advances 7(1):100521, published online 2025-09-22; PMC12547740 full-text XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.source_locator Results 'RNA splicing analysis reclassifies 54% of VUS' paragraph 1 Context-only references | Drost et al. 2025, Data S1 (Tables S1-S6) Results 'RNA splicing analysis reclassifies 54% of VUS' paragraph 1 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: mmc2.xlsx (Data S1. Tables S1-S6) inside the Europe PMC supplementaryFiles zip for PMC12547740 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of mmc2.xlsx as extracted from the supplementaryFiles zip (zip SHA-256 1c89a7ebc0bf686c6087d0fee86ba6f364a6d754d5bc7eb9c446b7db017f1ebc; the zip is re-built by Europe PMC on each request, so only the member hash is stable). |
| attributes.value In most cases (87%, n = 176/202) variants were identified as potentially spliceogenic by a laboratory specialist using Alamut Visual Plus (>10% change in 2 of 4 predictions) before RNA analysis was requested. Context-only references | Routine RNA-based analysis of potential splicing variants facilitates genomic diagnostics and reveals limitations of in silico prediction tools Results 'RNA splicing analysis reclassifies 54% of VUS' paragraph 1 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: HGG Advances 7(1):100521, published online 2025-09-22; PMC12547740 full-text XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| attributes.value In most cases (87%, n = 176/202) variants were identified as potentially spliceogenic by a laboratory specialist using Alamut Visual Plus (>10% change in 2 of 4 predictions) before RNA analysis was requested. Context-only references | Drost et al. 2025, Data S1 (Tables S1-S6) Results 'RNA splicing analysis reclassifies 54% of VUS' paragraph 1 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: mmc2.xlsx (Data S1. Tables S1-S6) inside the Europe PMC supplementaryFiles zip for PMC12547740 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of mmc2.xlsx as extracted from the supplementaryFiles zip (zip SHA-256 1c89a7ebc0bf686c6087d0fee86ba6f364a6d754d5bc7eb9c446b7db017f1ebc; the zip is re-built by Europe PMC on each request, so only the member hash is stable). |
| description Descriptive fact transcribed from the pinned source. Context-only references | Routine RNA-based analysis of potential splicing variants facilitates genomic diagnostics and reveals limitations of in silico prediction tools Results 'RNA splicing analysis reclassifies 54% of VUS' paragraph 1 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: HGG Advances 7(1):100521, published online 2025-09-22; PMC12547740 full-text XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| description Descriptive fact transcribed from the pinned source. Context-only references | Drost et al. 2025, Data S1 (Tables S1-S6) Results 'RNA splicing analysis reclassifies 54% of VUS' paragraph 1 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: mmc2.xlsx (Data S1. Tables S1-S6) inside the Europe PMC supplementaryFiles zip for PMC12547740 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of mmc2.xlsx as extracted from the supplementaryFiles zip (zip SHA-256 1c89a7ebc0bf686c6087d0fee86ba6f364a6d754d5bc7eb9c446b7db017f1ebc; the zip is re-built by Europe PMC on each request, so only the member hash is stable). |
| Relationship: subject rna-splicing-20261009-data-drost2025-inhouse-subset Context-only references | Routine RNA-based analysis of potential splicing variants facilitates genomic diagnostics and reveals limitations of in silico prediction tools Results 'RNA splicing analysis reclassifies 54% of VUS' paragraph 1 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: HGG Advances 7(1):100521, published online 2025-09-22; PMC12547740 full-text XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Relationship: subject rna-splicing-20261009-data-drost2025-inhouse-subset Context-only references | Drost et al. 2025, Data S1 (Tables S1-S6) Results 'RNA splicing analysis reclassifies 54% of VUS' paragraph 1 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: mmc2.xlsx (Data S1. Tables S1-S6) inside the Europe PMC supplementaryFiles zip for PMC12547740 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of mmc2.xlsx as extracted from the supplementaryFiles zip (zip SHA-256 1c89a7ebc0bf686c6087d0fee86ba6f364a6d754d5bc7eb9c446b7db017f1ebc; the zip is re-built by Europe PMC on each request, so only the member hash is stable). |
Sources and history
Release 2026-10-10-7b8f80935f90 · Record review: source checked
2 source records and release history
- Routine RNA-based analysis of potential splicing variants facilitates genomic diagnostics and reveals limitations of in silico prediction tools · Original source · HGG Advances 7(1):100521, published online 2025-09-22; PMC12547740 full-text XML
- Drost et al. 2025, Data S1 (Tables S1-S6) · Original source · mmc2.xlsx (Data S1. Tables S1-S6) inside the Europe PMC supplementaryFiles zip for PMC12547740
Technical metadata and extraction receipts
Stable ID: rna-splicing-20261009-claim-drost2025-alamut-selection
- field
- selection_bias
- value
- In most cases (87%, n = 176/202) variants were identified as potentially spliceogenic by a laboratory specialist using Alamut Visual Plus (>10% change in 2 of 4 predictions) before RNA analysis was requested.
- source locator
- Results 'RNA splicing analysis reclassifies 54% of VUS' paragraph 1
- review
- method: source-hash-verification; ai-assisted-source-review; reviewer: claude; reviewer note: Separate Claude review agent, independent of the extractor; no human review claimed; date: 2026-10-09; artifact sha256: a3a69202b8f0d9ecb7fa22a16991d5e4d583b5ae72fd598206ea5c2b4c5c14ca; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12547740/supplementaryFiles; method note: Compared the claim with the cited paragraphs of the re-downloaded article XML.; note: Hand transcription from the article XML text. Pending independent review. Independent review 2026-10-09: wording matches the source.