false_positive_cause: rna-pathogen-20261011-sanderson2026-protocol-validation
False positive cause of Target-level detection of respiratory pathogens against routine multiplex PCR, validation set (Sanderson et al. 2026)
All nine false-positive detections in the validation set were potentially attributable to barcode crossover from another sample on the same run with many reads for the same pathogen.
Descriptive fact transcribed from the pinned source.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
6 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Claimed field false_positive_cause Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance' paragraph 5 Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Source location Results 'Validation Set: Diagnostic performance' paragraph 5 Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance' paragraph 5 Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Claimed value All nine false-positive detections in the validation set were potentially attributable to barcode crossover from another sample on the same run with many reads for the same pathogen. Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance' paragraph 5 Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Description Descriptive fact transcribed from the pinned source. Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance' paragraph 5 Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Relationship: subject rna-pathogen-20261011-sanderson2026-protocol-validation Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance' paragraph 5 Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Name false_positive_cause: rna-pathogen-20261011-sanderson2026-protocol-validation Context-only references | Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study Results 'Validation Set: Diagnostic performance' paragraph 5 Version: medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study · Original source · medRxiv 10.64898/2026.02.06.26345651 v2, posted 2026-02-26; JATS XML
Technical metadata and extraction receipts
Stable ID: rna-pathogen-20261011-sanderson2026-claim-false-positive-cause
- field
- false_positive_cause
- value
- All nine false-positive detections in the validation set were potentially attributable to barcode crossover from another sample on the same run with many reads for the same pathogen.
- source locator
- Results 'Validation Set: Diagnostic performance' paragraph 5
- review
- method: source-hash-verification; independent-cell-check; scope-review; reviewer: claude; reviewer note: Separate Claude review agent (reviewer-path), independent of the extractor; no human review claimed; date: 2026-10-11; artifact sha256: c0bc5c035742f53fe291e08b9d956102e102fd743a55de503f00bcaead36a7e2; retrieval url: https://www.medrxiv.org/content/early/2026/02/26/2026.02.06.26345651.source.xml; method note: Transcribed from the pinned JATS XML text.; note: Re-downloaded the pinned artifact and matched its SHA-256; compared every value with a separate stdlib parser written for this review (the extractor's script was not run) and checked a stratified sample by hand against the rendered table.