ESM2 OFS pseudo-perplexity: description
Description of ESM2 OFS pseudo-perplexity
Estimates protein fitness from the negative pseudo-perplexity of a sequence, approximated in a single unmasked forward pass by an ensemble of eight multilayer perceptrons that predict the ESM-2 650M masked residue profiles.
Replace a placeholder description with a sourced functional description (issue #88). Historical releases retain the original value.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
14 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Claimed field description Context-only references | Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation Reviewed profile (2026-09-16): summary at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; architecture fact at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; description text also read at Abstract; Section III Pseudo-perplexity in one fell swoop Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: PRX Life 2025 journal article | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Claimed field description Context-only references | facebookresearch/esm README.md Reviewed profile (2026-09-16): summary at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; architecture fact at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; description text also read at Abstract; Section III Pseudo-perplexity in one fell swoop Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 2b369911bb5b4b0dda914521b9475cad1656b2ac | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Previous value Identity as reported in this paper. Unspecified versions are not assumed equivalent to other papers. Context-only references | Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation Reviewed profile (2026-09-16): summary at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; architecture fact at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; description text also read at Abstract; Section III Pseudo-perplexity in one fell swoop Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: PRX Life 2025 journal article | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Previous value Identity as reported in this paper. Unspecified versions are not assumed equivalent to other papers. Context-only references | facebookresearch/esm README.md Reviewed profile (2026-09-16): summary at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; architecture fact at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; description text also read at Abstract; Section III Pseudo-perplexity in one fell swoop Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 2b369911bb5b4b0dda914521b9475cad1656b2ac | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Source location Reviewed profile (2026-09-16): summary at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; architecture fact at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; description text also read at Abstract; Section III Pseudo-perplexity in one fell swoop Context-only references | Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation Reviewed profile (2026-09-16): summary at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; architecture fact at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; description text also read at Abstract; Section III Pseudo-perplexity in one fell swoop Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: PRX Life 2025 journal article | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Source location Reviewed profile (2026-09-16): summary at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; architecture fact at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; description text also read at Abstract; Section III Pseudo-perplexity in one fell swoop Context-only references | facebookresearch/esm README.md Reviewed profile (2026-09-16): summary at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; architecture fact at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; description text also read at Abstract; Section III Pseudo-perplexity in one fell swoop Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 2b369911bb5b4b0dda914521b9475cad1656b2ac | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Claimed value Estimates protein fitness from the negative pseudo-perplexity of a sequence, approximated in a single unmasked forward pass by an ensemble of eight multilayer perceptrons that predict the ESM-2 650M masked residue profiles. Context-only references | Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation Reviewed profile (2026-09-16): summary at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; architecture fact at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; description text also read at Abstract; Section III Pseudo-perplexity in one fell swoop Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: PRX Life 2025 journal article | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Claimed value Estimates protein fitness from the negative pseudo-perplexity of a sequence, approximated in a single unmasked forward pass by an ensemble of eight multilayer perceptrons that predict the ESM-2 650M masked residue profiles. Context-only references | facebookresearch/esm README.md Reviewed profile (2026-09-16): summary at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; architecture fact at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; description text also read at Abstract; Section III Pseudo-perplexity in one fell swoop Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 2b369911bb5b4b0dda914521b9475cad1656b2ac | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Description Replace a placeholder description with a sourced functional description (issue #88). Historical releases retain the original value. Context-only references | Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation Reviewed profile (2026-09-16): summary at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; architecture fact at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; description text also read at Abstract; Section III Pseudo-perplexity in one fell swoop Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: PRX Life 2025 journal article | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Description Replace a placeholder description with a sourced functional description (issue #88). Historical releases retain the original value. Context-only references | facebookresearch/esm README.md Reviewed profile (2026-09-16): summary at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; architecture fact at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; description text also read at Abstract; Section III Pseudo-perplexity in one fell swoop Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 2b369911bb5b4b0dda914521b9475cad1656b2ac | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
Release 2026-11-02-a7f03c9e55a5 · Record review: source checked
2 source records and release history
- Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation · Original source · PRX Life 2025 journal article
- facebookresearch/esm README.md · Original source · 2b369911bb5b4b0dda914521b9475cad1656b2ac
Technical metadata and extraction receipts
Stable ID: metadata-correction-d56cf2d281c9946307e0
- areas
- proteins-complexes
- field
- description
- previous value
- Identity as reported in this paper. Unspecified versions are not assumed equivalent to other papers.
- value
- Estimates protein fitness from the negative pseudo-perplexity of a sequence, approximated in a single unmasked forward pass by an ensemble of eight multilayer perceptrons that predict the ESM-2 650M masked residue profiles.
- source locator
- Reviewed profile (2026-09-16): summary at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; architecture fact at Section III, One Fell Swoop; Figure 1; Section IV fitness evaluation; description text also read at Abstract; Section III Pseudo-perplexity in one fell swoop
- review
- method: automated-source-review; ai-assisted-source-review; reviewer: claude; reviewer note: Extractor: Claude integrator agent for issue #88. Reviewer: a separate Claude review agent, independent of the extractor; no human review claimed.; date: 2026-10-11; method note: Compared the store diff with origin/main, read each new description against its cited source passage and checked the licence of each new source record.; note: Approved. Checked all 11 scTab and MPRabc method descriptions against PMC11298532 and PMC13232518, and Lazypipe-nt, scaLR, CATHe2, DiffDock-NMDN, PC-mer and Hi-Enhancer against their papers; all match. The other pipeline descriptions are consistent with their pinned papers.; receipt: data/omics/qa-descriptions-20261011-c/review.json
Related records
- subject: ESM2 OFS pseudo-perplexity