rewirebio.iobenchmarks
Evidence claim

VESPAl: description

Description of VESPAl

Light version of VESPA that predicts single amino acid variant effects from predicted conservation and BLOSUM62 scores only, without the language-model substitution probabilities, scored in ProteinGym as a zero-shot substitution baseline.

Replace a placeholder or provenance description with a sourced functional description (issue #88a). Historical releases retain the original value.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

14 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statementOriginal source and locationReview and provenance
Claimed field
description
Context-only references
Embeddings from protein language models predict conservation and variant effects (full text)

Original source ↗

uc20260930-source-proteingym-amfr-spearman: Benchmark CSV header (model scored in the zero-shot DMS substitution benchmark); qa-descriptions-20261010-source-vespa-full: Methods 'Supervised prediction of SAV effect scores (VESPA and VESPAl)'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Human Genetics 141:1629-1647, 2022; PMC8716573 full-text XML
Retrieved: 2026-10-10T06:46:14Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.field

Source artifact SHA-256: 042095fb9da6f1a9ed623768fbb86212af6b8d2b78949d9038f966bf65bd8e8b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Claimed field
description
Context-only references
ProteinGym AMFR assay-level Spearman comparison

Original source ↗

uc20260930-source-proteingym-amfr-spearman: Benchmark CSV header (model scored in the zero-shot DMS substitution benchmark); qa-descriptions-20261010-source-vespa-full: Methods 'Supervised prediction of SAV effect scores (VESPA and VESPAl)'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c
Retrieved: 2026-09-30

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.field

Source artifact SHA-256: f432423b87f79ac9778dfac86e3d95be041d246bc618dc0a406b35b0b7466437

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Previous value
Named prediction model family identified in the cited primary source. Exact fitted configurations and scores are separate records.
Context-only references
Embeddings from protein language models predict conservation and variant effects (full text)

Original source ↗

uc20260930-source-proteingym-amfr-spearman: Benchmark CSV header (model scored in the zero-shot DMS substitution benchmark); qa-descriptions-20261010-source-vespa-full: Methods 'Supervised prediction of SAV effect scores (VESPA and VESPAl)'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Human Genetics 141:1629-1647, 2022; PMC8716573 full-text XML
Retrieved: 2026-10-10T06:46:14Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.previous_value

Source artifact SHA-256: 042095fb9da6f1a9ed623768fbb86212af6b8d2b78949d9038f966bf65bd8e8b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Previous value
Named prediction model family identified in the cited primary source. Exact fitted configurations and scores are separate records.
Context-only references
ProteinGym AMFR assay-level Spearman comparison

Original source ↗

uc20260930-source-proteingym-amfr-spearman: Benchmark CSV header (model scored in the zero-shot DMS substitution benchmark); qa-descriptions-20261010-source-vespa-full: Methods 'Supervised prediction of SAV effect scores (VESPA and VESPAl)'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c
Retrieved: 2026-09-30

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.previous_value

Source artifact SHA-256: f432423b87f79ac9778dfac86e3d95be041d246bc618dc0a406b35b0b7466437

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Source location
uc20260930-source-proteingym-amfr-spearman: Benchmark CSV header (model scored in the zero-shot DMS substitution benchmark); qa-descriptions-20261010-source-vespa-full: Methods 'Supervised prediction of SAV effect scores (VESPA and VESPAl)'
Context-only references
Embeddings from protein language models predict conservation and variant effects (full text)

Original source ↗

uc20260930-source-proteingym-amfr-spearman: Benchmark CSV header (model scored in the zero-shot DMS substitution benchmark); qa-descriptions-20261010-source-vespa-full: Methods 'Supervised prediction of SAV effect scores (VESPA and VESPAl)'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Human Genetics 141:1629-1647, 2022; PMC8716573 full-text XML
Retrieved: 2026-10-10T06:46:14Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.source_locator

Source artifact SHA-256: 042095fb9da6f1a9ed623768fbb86212af6b8d2b78949d9038f966bf65bd8e8b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Source location
uc20260930-source-proteingym-amfr-spearman: Benchmark CSV header (model scored in the zero-shot DMS substitution benchmark); qa-descriptions-20261010-source-vespa-full: Methods 'Supervised prediction of SAV effect scores (VESPA and VESPAl)'
Context-only references
ProteinGym AMFR assay-level Spearman comparison

Original source ↗

uc20260930-source-proteingym-amfr-spearman: Benchmark CSV header (model scored in the zero-shot DMS substitution benchmark); qa-descriptions-20261010-source-vespa-full: Methods 'Supervised prediction of SAV effect scores (VESPA and VESPAl)'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c
Retrieved: 2026-09-30

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.source_locator

Source artifact SHA-256: f432423b87f79ac9778dfac86e3d95be041d246bc618dc0a406b35b0b7466437

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Claimed value
Light version of VESPA that predicts single amino acid variant effects from predicted conservation and BLOSUM62 scores only, without the language-model substitution probabilities, scored in ProteinGym as a zero-shot substitution baseline.
Context-only references
Embeddings from protein language models predict conservation and variant effects (full text)

Original source ↗

uc20260930-source-proteingym-amfr-spearman: Benchmark CSV header (model scored in the zero-shot DMS substitution benchmark); qa-descriptions-20261010-source-vespa-full: Methods 'Supervised prediction of SAV effect scores (VESPA and VESPAl)'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Human Genetics 141:1629-1647, 2022; PMC8716573 full-text XML
Retrieved: 2026-10-10T06:46:14Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.value

Source artifact SHA-256: 042095fb9da6f1a9ed623768fbb86212af6b8d2b78949d9038f966bf65bd8e8b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Claimed value
Light version of VESPA that predicts single amino acid variant effects from predicted conservation and BLOSUM62 scores only, without the language-model substitution probabilities, scored in ProteinGym as a zero-shot substitution baseline.
Context-only references
ProteinGym AMFR assay-level Spearman comparison

Original source ↗

uc20260930-source-proteingym-amfr-spearman: Benchmark CSV header (model scored in the zero-shot DMS substitution benchmark); qa-descriptions-20261010-source-vespa-full: Methods 'Supervised prediction of SAV effect scores (VESPA and VESPAl)'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c
Retrieved: 2026-09-30

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.value

Source artifact SHA-256: f432423b87f79ac9778dfac86e3d95be041d246bc618dc0a406b35b0b7466437

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Description
Replace a placeholder or provenance description with a sourced functional description (issue #88a). Historical releases retain the original value.
Context-only references
Embeddings from protein language models predict conservation and variant effects (full text)

Original source ↗

uc20260930-source-proteingym-amfr-spearman: Benchmark CSV header (model scored in the zero-shot DMS substitution benchmark); qa-descriptions-20261010-source-vespa-full: Methods 'Supervised prediction of SAV effect scores (VESPA and VESPAl)'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Human Genetics 141:1629-1647, 2022; PMC8716573 full-text XML
Retrieved: 2026-10-10T06:46:14Z

not individually reviewed

No individual claim review recorded

Audit details

Field: description

Source artifact SHA-256: 042095fb9da6f1a9ed623768fbb86212af6b8d2b78949d9038f966bf65bd8e8b

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Description
Replace a placeholder or provenance description with a sourced functional description (issue #88a). Historical releases retain the original value.
Context-only references
ProteinGym AMFR assay-level Spearman comparison

Original source ↗

uc20260930-source-proteingym-amfr-spearman: Benchmark CSV header (model scored in the zero-shot DMS substitution benchmark); qa-descriptions-20261010-source-vespa-full: Methods 'Supervised prediction of SAV effect scores (VESPA and VESPAl)'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c
Retrieved: 2026-09-30

not individually reviewed

No individual claim review recorded

Audit details

Field: description

Source artifact SHA-256: f432423b87f79ac9778dfac86e3d95be041d246bc618dc0a406b35b0b7466437

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

2 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: metadata-correction-7527b96f9938e64b7b45

areas
proteins-complexes
field
description
previous value
Named prediction model family identified in the cited primary source. Exact fitted configurations and scores are separate records.
value
Light version of VESPA that predicts single amino acid variant effects from predicted conservation and BLOSUM62 scores only, without the language-model substitution probabilities, scored in ProteinGym as a zero-shot substitution baseline.
source locator
uc20260930-source-proteingym-amfr-spearman: Benchmark CSV header (model scored in the zero-shot DMS substitution benchmark); qa-descriptions-20261010-source-vespa-full: Methods 'Supervised prediction of SAV effect scores (VESPA and VESPAl)'
review
method: automated-source-review; ai-assisted-source-review; reviewer: claude; reviewer note: Extractor: Claude research agent for issue #88a. Reviewer: separate Claude review agent, independent of the extractor; no human review claimed; date: 2026-10-10; method note: Compared the description with the cited source text (abstract, README row, benchmark CSV header or full-text section) of re-downloaded artifacts, and previous_value with origin/main.; note: Description written from the cited source text; provenance text was generic and is kept here as previous_value. Independent review 2026-10-10: every stated fact is supported by the cited text.
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