MutScore: description
Description of MutScore
Random forest that combines qualitative features of the DNA substitution with the within-gene positional clustering of pathogenic and benign missense variants.
Replace a category-only description with a sourced functional description (issue #88). Historical releases retain the original value.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
7 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Claimed field description Context-only references | Analysis of missense variants in the human genome reveals widespread gene-specific clustering and improves prediction of pathogenicity (MutScore) qa-descriptions-20261011-e-source-mutscore: Summary Version: Europe PMC full-text XML for PMC8948164, American Journal of Human Genetics 2022 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the Europe PMC full-text XML. These renderings are not always byte-stable; the article text is the evidence. |
| Previous value Variant effect predictor for missense variants. Context-only references | Analysis of missense variants in the human genome reveals widespread gene-specific clustering and improves prediction of pathogenicity (MutScore) qa-descriptions-20261011-e-source-mutscore: Summary Version: Europe PMC full-text XML for PMC8948164, American Journal of Human Genetics 2022 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the Europe PMC full-text XML. These renderings are not always byte-stable; the article text is the evidence. |
| Source location qa-descriptions-20261011-e-source-mutscore: Summary Context-only references | Analysis of missense variants in the human genome reveals widespread gene-specific clustering and improves prediction of pathogenicity (MutScore) qa-descriptions-20261011-e-source-mutscore: Summary Version: Europe PMC full-text XML for PMC8948164, American Journal of Human Genetics 2022 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the Europe PMC full-text XML. These renderings are not always byte-stable; the article text is the evidence. |
| Claimed value Random forest that combines qualitative features of the DNA substitution with the within-gene positional clustering of pathogenic and benign missense variants. Context-only references | Analysis of missense variants in the human genome reveals widespread gene-specific clustering and improves prediction of pathogenicity (MutScore) qa-descriptions-20261011-e-source-mutscore: Summary Version: Europe PMC full-text XML for PMC8948164, American Journal of Human Genetics 2022 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the Europe PMC full-text XML. These renderings are not always byte-stable; the article text is the evidence. |
| Description Replace a category-only description with a sourced functional description (issue #88). Historical releases retain the original value. Context-only references | Analysis of missense variants in the human genome reveals widespread gene-specific clustering and improves prediction of pathogenicity (MutScore) qa-descriptions-20261011-e-source-mutscore: Summary Version: Europe PMC full-text XML for PMC8948164, American Journal of Human Genetics 2022 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the Europe PMC full-text XML. These renderings are not always byte-stable; the article text is the evidence. |
| Relationship: subject somatic-oncogenicity-20261009-method-mutscore Context-only references | Analysis of missense variants in the human genome reveals widespread gene-specific clustering and improves prediction of pathogenicity (MutScore) qa-descriptions-20261011-e-source-mutscore: Summary Version: Europe PMC full-text XML for PMC8948164, American Journal of Human Genetics 2022 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the Europe PMC full-text XML. These renderings are not always byte-stable; the article text is the evidence. |
| Name MutScore: description Context-only references | Analysis of missense variants in the human genome reveals widespread gene-specific clustering and improves prediction of pathogenicity (MutScore) qa-descriptions-20261011-e-source-mutscore: Summary Version: Europe PMC full-text XML for PMC8948164, American Journal of Human Genetics 2022 | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the Europe PMC full-text XML. These renderings are not always byte-stable; the article text is the evidence. |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Analysis of missense variants in the human genome reveals widespread gene-specific clustering and improves prediction of pathogenicity (MutScore) · Original source · Europe PMC full-text XML for PMC8948164, American Journal of Human Genetics 2022
Technical metadata and extraction receipts
Stable ID: metadata-correction-0ea254941d2fb84e578a
- areas
- dna-genomes
- contexts
- clinical_research
- method types
- supervised_machine_learning
- field
- description
- previous value
- Variant effect predictor for missense variants.
- value
- Random forest that combines qualitative features of the DNA substitution with the within-gene positional clustering of pathogenic and benign missense variants.
- source locator
- qa-descriptions-20261011-e-source-mutscore: Summary
- review
- method: automated-source-review; ai-assisted-source-review; reviewer: claude; reviewer note: Extractor: Claude integrator agent for issue #88. Reviewer: a separate Claude review agent, independent of the extractor; no human review claimed.; date: 2026-10-11; method note: Compared the store diff with origin/main, read each new description against its cited source passage and checked the licence of each new source record.; note: Approved with two corrections, both applied: the MutFormer source licence is CC BY 4.0 per the arXiv abstract page, and the MetaRNN source locator now names the Background passage. Checked the 27 Chen 2020 descriptions row by row against Table 1 (PMC7033911) and spot-checked AlphaMissense, MisFit, popEVE, VARITY, MetaRNN, MutFormer and gMVP against their abstracts; accurate. Licences on the other new sources match Europe PMC.; receipt: data/omics/qa-descriptions-20261011-e/review.json
Related records
- subject: MutScore