rewirebio.iobenchmarks
Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

  • 121open
  • 5settled
  • 7resolved
  • 1medium severity
  • 132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

Showing findings that compare VEST4. All models

2 findings match, most severe first.

VEST4 and ESM-1b: Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) reverses the order

  • Low severity
  • Not yet reviewed
  • Ordering reversal
  • Same task, different protocols

Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks ESM-1b above VEST4 in 6 of 7 comparisons; 2 of 2 other studies rank VEST4 above ESM-1b.

2 papers rank VEST4 above ESM-1b in 7 of their 10 comparisons and ESM-1b higher in 1; 2 are ties. Livesey and Marsh 2025 ranks ESM-1b above VEST4 in 6 of its 7 comparisons and VEST4 higher in 1.

Comparisons in which each paper scores VEST4 or ESM-1b higher2 other papers: VEST4 higher in 7, ESM-1b higher in 1, 2 ties. Livesey and Marsh 2025 (disagrees): VEST4 higher in 1, ESM-1b higher in 6, 0 ties.2 other papers7 VEST4 higher72 tie21 ESM-1b higher1Disagrees: Livesey and Marsh 2025Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML)1 VEST4 higher16 ESM-1b higher6
VEST4 higherTieESM-1b higher
Compared
VEST4, ESM-1b

Not reviewed yet.

MutFormer and VEST4: Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) and An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers disagree

  • Low severity
  • Not yet reviewed
  • two-study-conflict
  • unknown

Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks MutFormer above VEST4 in 6 of 7 comparisons; An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers ranks VEST4 above MutFormer in 6 of 6 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank MutFormer above VEST4 in 6 of their 13 comparisons and VEST4 higher in 7. Of those papers, An openly licensed benchmark… ranks VEST4 higher on its own (6 of 6).

Comparisons in which each paper scores MutFormer or VEST4 higher2 other papers: MutFormer higher in 6, VEST4 higher in 7, 0 ties.2 other papers6 MutFormer higher67 VEST4 higher7
MutFormer higherTieVEST4 higher
Compared
MutFormer, VEST4

Not reviewed yet.