rewirebio.iobenchmarks
Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

  • 121open
  • 5settled
  • 7resolved
  • 1medium severity
  • 132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

Showing findings that compare MPC. All models

2 findings match, most severe first.

MPC and MutationAssessor: Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) reverses the order

  • Low severity
  • Not yet reviewed
  • Ordering reversal
  • unknown

Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks MutationAssessor above MPC in 6 of 7 comparisons; 2 of 2 other studies rank MPC above MutationAssessor.

2 papers rank MPC above MutationAssessor in all 16 of their comparisons. Livesey and Marsh 2025 ranks MutationAssessor above MPC in 6 of its 7 comparisons and MPC higher in 1.

Comparisons in which each paper scores MPC or MutationAssessor higher2 other papers: MPC higher in 16, MutationAssessor higher in 0, 0 ties. Livesey and Marsh 2025 (disagrees): MPC higher in 1, MutationAssessor higher in 6, 0 ties.2 other papers16 MPC higher16Disagrees: Livesey and Marsh 2025Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML)1 MPC higher16 MutationAssessor higher6
MPC higherTieMutationAssessor higher
Compared
MPC, MutationAssessor

Not reviewed yet.

MPC and MutFormer: Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) and An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers disagree

  • Low severity
  • Not yet reviewed
  • two-study-conflict
  • unknown

Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks MutFormer above MPC in 7 of 7 comparisons; An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers ranks MPC above MutFormer in 6 of 6 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank MPC above MutFormer in 6 of their 13 comparisons and MutFormer higher in 7. Of those papers, Livesey and Marsh 2025 ranks MutFormer higher on its own (7 of 7).

Comparisons in which each paper scores MPC or MutFormer higher2 other papers: MPC higher in 6, MutFormer higher in 7, 0 ties.2 other papers6 MPC higher67 MutFormer higher7
MPC higherTieMutFormer higher
Compared
MPC, MutFormer

Not reviewed yet.