rewirebio.iobenchmarks
Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

  • 121open
  • 5settled
  • 7resolved
  • 1medium severity
  • 132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

Showing findings that compare GERP. All models

2 findings match, most severe first.

DANN and GERP: Clinical likelihood ratios and balanced accuracy for 44 in silico tools against multiple large-scale functional assays of cancer susceptibility genes reverses the order

  • Low severity
  • Not yet reviewed
  • Ordering reversal
  • unknown

Clinical likelihood ratios and balanced accuracy for 44 in silico tools against multiple large-scale functional assays of cancer susceptibility genes ranks GERP above DANN in 5 of 6 comparisons; 2 of 2 other studies rank DANN above GERP.

2 papers rank DANN above GERP in all 12 comparisons that are not ties (1 is a tie). Clinical likelihood ratios and balanced… ranks GERP above DANN in 5 of its 6 comparisons and DANN higher in 1.

Comparisons in which each paper scores DANN or GERP higher2 other papers: DANN higher in 12, GERP higher in 0, 1 tie. Clinical likelihood ratios and balanced… (disagrees): DANN higher in 1, GERP higher in 5, 0 ties.2 other papers12 DANN higher121 tieDisagrees: Clinical likelihood ratios and balanced…Clinical likelihood ratios and balanced accuracy for 44 in silico tools against multiple large-scale functional assays of cancer susceptibility genes1 DANN higher15 GERP higher5
DANN higherTieGERP higher
Compared
DANN, GERP

Not reviewed yet.

SiPhy and GERP: Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods reverses the order

  • Low severity
  • Not yet reviewed
  • Ordering reversal
  • Same task, different protocols

Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods ranks SiPhy above GERP in 4 of 4 comparisons; 2 of 2 other studies rank GERP above SiPhy.

2 papers rank GERP above SiPhy in 11 of their 13 comparisons and SiPhy higher in 1; 1 is a tie. Brandes et al. 2023 ranks SiPhy above GERP in all 4 of its comparisons.

Comparisons in which each paper scores GERP or SiPhy higher2 other papers: GERP higher in 11, SiPhy higher in 1, 1 tie. Brandes et al. 2023 (disagrees): GERP higher in 0, SiPhy higher in 4, 0 ties.2 other papers11 GERP higher111 tie1 SiPhy higherDisagrees: Brandes et al. 2023Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods4 SiPhy higher4
GERP higherTieSiPhy higher
Compared
SiPhy, GERP

Not reviewed yet.