rewirebio.iobenchmarks
Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

  • 121open
  • 5settled
  • 7resolved
  • 1medium severity
  • 132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

Showing findings that compare GenoCanyon. All models

3 findings match, most severe first.

GenoCanyon and SIFT: Comprehensive assessment of computational algorithms in predicting cancer driver mutations reverses the order

  • Low severity
  • Not yet reviewed
  • Ordering reversal
  • unknown

Comprehensive assessment of computational algorithms in predicting cancer driver mutations ranks GenoCanyon above SIFT in 6 of 8 comparisons; 3 of 3 other studies rank SIFT above GenoCanyon.

3 papers rank SIFT above GenoCanyon in 14 of their 16 comparisons and GenoCanyon higher in 1; 1 is a tie. Comprehensive assessment… ranks GenoCanyon above SIFT in 6 of its 10 comparisons and SIFT higher in 2; 2 are ties.

Comparisons in which each paper scores SIFT or GenoCanyon higher3 other papers: SIFT higher in 14, GenoCanyon higher in 1, 1 tie. Comprehensive assessment… (disagrees): SIFT higher in 2, GenoCanyon higher in 6, 2 ties.3 other papers14 SIFT higher141 tie1 GenoCanyon higherDisagrees: Comprehensive assessment…Comprehensive assessment of computational algorithms in predicting cancer driver mutations2 SIFT higher22 tie26 GenoCanyon higher6
SIFT higherTieGenoCanyon higher
Compared
GenoCanyon, SIFT

Not reviewed yet.

GenoCanyon and phyloP: Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods reverses the order

  • Low severity
  • Not yet reviewed
  • Ordering reversal
  • Same task, different protocols

Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods ranks GenoCanyon above phyloP in 3 of 3 comparisons; 2 of 2 other studies rank phyloP above GenoCanyon.

2 papers rank phyloP above GenoCanyon in 11 of their 13 comparisons and GenoCanyon higher in 1; 1 is a tie. Brandes et al. 2023 ranks GenoCanyon above phyloP in all 3 comparisons that are not ties (1 is a tie).

Comparisons in which each paper scores phyloP or GenoCanyon higher2 other papers: phyloP higher in 11, GenoCanyon higher in 1, 1 tie. Brandes et al. 2023 (disagrees): phyloP higher in 0, GenoCanyon higher in 3, 1 tie.2 other papers11 phyloP higher111 tie1 GenoCanyon higherDisagrees: Brandes et al. 2023Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods1 tie13 GenoCanyon higher3
phyloP higherTieGenoCanyon higher
Compared
GenoCanyon, phyloP

Not reviewed yet.

GenoCanyon and MetaSVM: Comprehensive assessment of computational algorithms in predicting cancer driver mutations reverses the order

  • Low severity
  • Not yet reviewed
  • Ordering reversal
  • unknown

Comprehensive assessment of computational algorithms in predicting cancer driver mutations ranks GenoCanyon above MetaSVM in 6 of 8 comparisons; 2 of 2 other studies rank MetaSVM above GenoCanyon.

2 papers rank MetaSVM above GenoCanyon in 12 of their 13 comparisons and GenoCanyon higher in 1. Comprehensive assessment… ranks GenoCanyon above MetaSVM in 6 of its 10 comparisons and MetaSVM higher in 2; 2 are ties.

Comparisons in which each paper scores MetaSVM or GenoCanyon higher2 other papers: MetaSVM higher in 12, GenoCanyon higher in 1, 0 ties. Comprehensive assessment… (disagrees): MetaSVM higher in 2, GenoCanyon higher in 6, 2 ties.2 other papers12 MetaSVM higher121 GenoCanyon higherDisagrees: Comprehensive assessment…Comprehensive assessment of computational algorithms in predicting cancer driver mutations2 MetaSVM higher22 tie26 GenoCanyon higher6
MetaSVM higherTieGenoCanyon higher
Compared
GenoCanyon, MetaSVM

Not reviewed yet.