rewirebio.iobenchmarks
Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

  • 121open
  • 5settled
  • 7resolved
  • 1medium severity
  • 132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

Showing findings that compare VARITY. All models

3 findings match, most severe first.

MetaRNN and VARITY: Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) and An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers disagree

  • Low severity
  • Not yet reviewed
  • two-study-conflict
  • unknown

Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks VARITY above MetaRNN in 6 of 7 comparisons; An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers ranks MetaRNN above VARITY in 3 of 4 comparisons. No other study gives a verdict, so neither is the outlier.

3 papers rank MetaRNN above VARITY in 5 of their 14 comparisons and VARITY higher in 7; 2 are ties. Of those papers, Livesey and Marsh 2025 ranks VARITY higher on its own (6 of 7).

Comparisons in which each paper scores MetaRNN or VARITY higher3 other papers: MetaRNN higher in 5, VARITY higher in 7, 2 ties.3 other papers5 MetaRNN higher52 tie27 VARITY higher7
MetaRNN higherTieVARITY higher
Compared
MetaRNN, VARITY

Not reviewed yet.

MutScore and VARITY: Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) and An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers disagree

  • Low severity
  • Not yet reviewed
  • two-study-conflict
  • unknown

Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks VARITY above MutScore in 6 of 7 comparisons; An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers ranks MutScore above VARITY in 4 of 4 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank MutScore above VARITY in 5 of their 13 comparisons and VARITY higher in 6; 2 are ties. Of those papers, Livesey and Marsh 2025 ranks VARITY higher on its own (6 of 7).

Comparisons in which each paper scores MutScore or VARITY higher2 other papers: MutScore higher in 5, VARITY higher in 6, 2 ties.2 other papers5 MutScore higher52 tie26 VARITY higher6
MutScore higherTieVARITY higher
Compared
MutScore, VARITY

Not reviewed yet.

ClinPred and VARITY: Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) and An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers disagree

  • Low severity
  • Not yet reviewed
  • two-study-conflict
  • unknown

Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks VARITY above ClinPred in 7 of 7 comparisons; An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers ranks ClinPred above VARITY in 4 of 4 comparisons. No other study gives a verdict, so neither is the outlier.

3 papers rank ClinPred above VARITY in 5 of their 14 comparisons and VARITY higher in 7; 2 are ties. Of those papers, Livesey and Marsh 2025 ranks VARITY higher on its own (7 of 7).

Comparisons in which each paper scores ClinPred or VARITY higher3 other papers: ClinPred higher in 5, VARITY higher in 7, 2 ties.3 other papers5 ClinPred higher52 tie27 VARITY higher7
ClinPred higherTieVARITY higher
Compared
ClinPred, VARITY

Not reviewed yet.