Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

121open
5settled
7resolved
1medium severity
132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

Showing findings that compare MutationTaster. All models

1 finding matches, most severe first.

MutationTaster and ESM-1b: Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods and An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers disagree

Low severity
Not yet reviewed
two-study-conflict
unknown

Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods ranks ESM-1b above MutationTaster in 4 of 4 comparisons; An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers ranks MutationTaster above ESM-1b in 5 of 5 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank MutationTaster above ESM-1b in 5 of their 10 comparisons and ESM-1b higher in 4; 1 is a tie. Of those papers, Brandes et al. 2023 ranks ESM-1b higher on its own (4 of 4).

MutationTaster higherTieESM-1b higher

Compared: MutationTaster, ESM-1b

Not reviewed yet.