Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

121open
5settled
7resolved
1medium severity
132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

Showing findings that compare PANTHER. All models

1 finding matches, most severe first.

PANTHER and SIFT: Clinical likelihood ratios and balanced accuracy for 44 in silico tools against multiple large-scale functional assays of cancer susceptibility genes and Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) disagree

Low severity
Not yet reviewed
two-study-conflict
unknown

Clinical likelihood ratios and balanced accuracy for 44 in silico tools against multiple large-scale functional assays of cancer susceptibility genes ranks SIFT above PANTHER in 3 of 4 comparisons; Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks PANTHER above SIFT in 5 of 6 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank PANTHER above SIFT in 6 of their 11 comparisons and SIFT higher in 4; 1 is a tie. Of those papers, Clinical likelihood ratios and balanced… ranks SIFT higher on its own (3 of 5).

PANTHER higherTieSIFT higher

Compared: PANTHER, SIFT

Not reviewed yet.