rewirebio.iobenchmarks
Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

  • 121open
  • 5settled
  • 7resolved
  • 1medium severity
  • 132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

Showing findings that compare FATHMM. All models

1 finding matches, most severe first.

FATHMM and Integrated_fitCons: Clinical likelihood ratios and balanced accuracy for 44 in silico tools against multiple large-scale functional assays of cancer susceptibility genes and Comprehensive assessment of computational algorithms in predicting cancer driver mutations disagree

  • Low severity
  • Not yet reviewed
  • two-study-conflict
  • unknown

Clinical likelihood ratios and balanced accuracy for 44 in silico tools against multiple large-scale functional assays of cancer susceptibility genes ranks FATHMM above Integrated_fitCons in 6 of 6 comparisons; Comprehensive assessment of computational algorithms in predicting cancer driver mutations ranks Integrated_fitCons above FATHMM in 8 of 9 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank FATHMM above Integrated_fitCons in 7 of their 16 comparisons and Integrated_fitCons higher in 8; 1 is a tie. Of those papers, Comprehensive assessment… ranks Integrated_fitCons higher on its own (8 of 10).

Comparisons in which each paper scores FATHMM or Integrated_fitCons higher2 other papers: FATHMM higher in 7, Integrated_fitCons higher in 8, 1 tie.2 other papers7 FATHMM higher71 tie8 Integrated_fitCons higher8
FATHMM higherTieIntegrated_fitCons higher
Compared
FATHMM, Integrated_fitCons

Not reviewed yet.