rewirebio.iobenchmarks
Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

  • 121open
  • 5settled
  • 7resolved
  • 1medium severity
  • 132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

Showing findings that compare phyloP. All models

4 findings match, most severe first.

GPN-MSA and phyloP: TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) reverses the order

  • Low severity
  • Not yet reviewed
  • Ordering reversal
  • unknown

TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) ranks phyloP above GPN-MSA in 2 of 2 comparisons; 2 of 2 other studies rank GPN-MSA above phyloP.

3 papers rank GPN-MSA above phyloP in 59 of their 67 comparisons and phyloP higher in 2; 6 are ties. TraitGym official metrics ranks phyloP above GPN-MSA in all 2 of its comparisons.

Comparisons in which each paper scores GPN-MSA or phyloP higher3 other papers: GPN-MSA higher in 59, phyloP higher in 2, 6 ties. TraitGym official metrics (disagrees): GPN-MSA higher in 0, phyloP higher in 2, 0 ties.3 other papers59 GPN-MSA higher596 tie2 phyloP higherDisagrees: TraitGym official metricsTraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym)2 phyloP higher2
GPN-MSA higherTiephyloP higher
Compared
GPN-MSA, phyloP

Not reviewed yet.

GenoCanyon and phyloP: Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods reverses the order

  • Low severity
  • Not yet reviewed
  • Ordering reversal
  • Same task, different protocols

Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods ranks GenoCanyon above phyloP in 3 of 3 comparisons; 2 of 2 other studies rank phyloP above GenoCanyon.

2 papers rank phyloP above GenoCanyon in 11 of their 13 comparisons and GenoCanyon higher in 1; 1 is a tie. Brandes et al. 2023 ranks GenoCanyon above phyloP in all 3 comparisons that are not ties (1 is a tie).

Comparisons in which each paper scores phyloP or GenoCanyon higher2 other papers: phyloP higher in 11, GenoCanyon higher in 1, 1 tie. Brandes et al. 2023 (disagrees): phyloP higher in 0, GenoCanyon higher in 3, 1 tie.2 other papers11 phyloP higher111 tie1 GenoCanyon higherDisagrees: Brandes et al. 2023Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods1 tie13 GenoCanyon higher3
phyloP higherTieGenoCanyon higher
Compared
GenoCanyon, phyloP

Not reviewed yet.

SiPhy and phyloP: Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods reverses the order

  • Low severity
  • Not yet reviewed
  • Ordering reversal
  • Same task, different protocols

Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods ranks SiPhy above phyloP in 3 of 4 comparisons; 2 of 2 other studies rank phyloP above SiPhy.

2 papers rank phyloP above SiPhy in all 13 of their comparisons. Brandes et al. 2023 ranks SiPhy above phyloP in 3 of its 4 comparisons and phyloP higher in 1.

Comparisons in which each paper scores phyloP or SiPhy higher2 other papers: phyloP higher in 13, SiPhy higher in 0, 0 ties. Brandes et al. 2023 (disagrees): phyloP higher in 1, SiPhy higher in 3, 0 ties.2 other papers13 phyloP higher13Disagrees: Brandes et al. 2023Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods1 phyloP higher13 SiPhy higher3
phyloP higherTieSiPhy higher
Compared
SiPhy, phyloP

Not reviewed yet.

MutFormer and phyloP: Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) and An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers disagree

  • Low severity
  • Not yet reviewed
  • two-study-conflict
  • unknown

Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks MutFormer above phyloP in 7 of 7 comparisons; An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers ranks phyloP above MutFormer in 4 of 5 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank MutFormer above phyloP in 8 of their 13 comparisons and phyloP higher in 4; 1 is a tie. Of those papers, An openly licensed benchmark… ranks phyloP higher on its own (4 of 6).

Comparisons in which each paper scores MutFormer or phyloP higher2 other papers: MutFormer higher in 8, phyloP higher in 4, 1 tie.2 other papers8 MutFormer higher81 tie4 phyloP higher4
MutFormer higherTiephyloP higher
Compared
MutFormer, phyloP

Not reviewed yet.