1.71 root-mean-squared-error
dieckhaus2024-acdc-nn-seq-fireprot root-mean-squared-error (Fireprot homologue-free split)
- Tested configuration
- ACDC-NN-Seq (Dieckhaus et al. 2024)
- Protocol
- Fireprot homologue-free split ddG prediction (Dieckhaus et al. 2024 Table 2)
- Dataset
- FireProtDB homologue-free split with experimental structures
- Procedure
- protein-stability-20261009-protocol-dieckhaus2024-fireprot
- Evaluation
- ACDC-NN-Seq on Fireprot homologue-free split (Dieckhaus et al. 2024)
- Coverage
- Not reported scored / Not reported eligible
- Uncertainty
- Not reported by the source
- Evidence
- Independent external evaluation · source checkedTransfer learning to leverage larger datasets for improved prediction of protein stability changes · Table 2, row 'ACDC-NN-Seq', column 'Fireprot RMSE (kcal/mol)'
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- Fireprot homologue-free split
- Adaptation
- Not reported
- Scoring implementation
- RMSE, Pearson and Spearman correlation
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 1.71 Individual claims | Transfer learning to leverage larger datasets for improved prediction of protein stability changes Table 2, row 'ACDC-NN-Seq', column 'Fireprot RMSE (kcal/mol)' Version: PNAS 121(6):e2314853121, published 2024-01-29; PMC10861915 full-text XML | source checked ["source-hash-verification","deterministic-table-parse","independent-cell-check"] · 2026-10-09 independent paper Audit detailsExtracted by deterministic parse of the table in the pinned JATS XML (extract/extract_protein_stability.py), with the caption, header rows and row labels asserted. printed_value is the cell text as printed, without footnote markers, which are kept in printed_source_cell. Independent review 2026-10-09: value and identity match the source. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Extraction artifact SHA-256: |
Sources and history
Release 2026-10-10-6e93f504adfc · Record review: source checked
1 source records and release history
- Transfer learning to leverage larger datasets for improved prediction of protein stability changes · Original source · PNAS 121(6):e2314853121, published 2024-01-29; PMC10861915 full-text XML
Technical metadata and extraction receipts
Stable ID: protein-stability-20261009-result-dieckhaus2024-acdc-nn-seq-fireprot-root-mean-squared-error
- metric
- root-mean-squared-error
- metric direction
- lower
- unit
- kilocalorie-per-mole
- metric qualifier
- Fireprot homologue-free split
- printed value
- 1.71
- numeric value
- 1.71
- source locator
- Table 2, row 'ACDC-NN-Seq', column 'Fireprot RMSE (kcal/mol)'
- missing metadata
- uncertainty: reason: unreported
- review
- method: source-hash-verification; deterministic-table-parse; independent-cell-check; method note: Re-downloaded the article XML and matched its SHA-256. Read the table with a separate parser (header rows, row labels, cell text with footnote markers); the extractor's script was not run. Checked printed and numeric value, footnote marker and warning, metric, qualifier, unit, direction and the linked configuration and protocol.; reviewer: claude; reviewer note: Separate Claude review agent, independent of the extractor; no human review claimed; date: 2026-10-09; artifact sha256: ba9a763c388eeea47d70fd0d8e2fbf497f61fc8a88dc93d5dac261572daa8010; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10861915/fullTextXML; note: Extracted by deterministic parse of the table in the pinned JATS XML (extract/extract_protein_stability.py), with the caption, header rows and row labels asserted. printed_value is the cell text as printed, without footnote markers, which are kept in printed_source_cell. Independent review 2026-10-09: value and identity match the source.
- printed source cell
- 1.71 *
- source warnings
- Score may be inflated due to the presence of close homologues (>25% sequence identity) of Fireprot proteins in the training dataset.