Result

0.0248 R²

ESM-2 · R² · PRIME mutated RBD

Tested configuration: ESM-2
Task: Mutated RBD binding prediction
Dataset: PRIME mutated RBD
Procedure: Frozen mean-pooled representation with downstream regression; position-stratified split.
Evaluation: ESM-2: Mutated RBD binding prediction
Coverage: scored: unreported; eligible: unreported
Uncertainty: ± 0.01
Evidence: Independent external evaluation · source checkedPRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: needs review. Source checked does not mean independently reproduced.

Reproduction

Split: position-stratified
Adaptation: Not reported
Scoring implementation: Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Access requirements and official instructions: Mutated RBD binding prediction

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

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1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-09-29-06401fd5b220
Property and statement	Original source and location	Review and provenance
attributes.printed_value 0.0248 Individual claims	PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space Original source ↗ Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column Version: version of record Retrieved: 2026-09-16T10:41:16.525183+00:00	source checked independent ai table review · 2026-09-16T10:41:16.525183+00:00 independent paper Audit details Resolved model row spans and Mean/CLS subrows in JATS: selected Mean, not fine-tuned (cross), Position-Stratified Split > Binding > R-squared. Central value agrees; uncertainty is retained in evidence. This verifies the central score at its source location, not every metadata field or an experimental reproduction. Field: `attributes.printed_value` Claim: claim-lit-021 Source artifact SHA-256: `f6aac4c25dd93026f87ce9a2e327c95faf4c3014d7f9ae04bb11f208ce047971` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact Extraction artifact SHA-256: `f6aac4c25dd93026f87ce9a2e327c95faf4c3014d7f9ae04bb11f208ce047971` Extraction artifact

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Release 2026-09-29-06401fd5b220 · Record review: source checked

1 source records and release history

PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space · Original source · version of record

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Technical metadata and extraction receipts

Stable ID: lit-021

areas: proteins-complexes
tasks: Mutated RBD binding prediction
printed value: 0.0248
numeric value: 0.0248
metric: R²
metric direction: unknown
unit: unitless
uncertainty: ± 0.01
source locator: Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column
review: method: independent_ai_table_review; reviewer: Codex omics research agent; independent source-table review, not human review; reviewed at: 2026-09-16T10:41:16.525183+00:00; notes: Resolved model row spans and Mean/CLS subrows in JATS: selected Mean, not fine-tuned (cross), Position-Stratified Split > Binding > R-squared. Central value agrees; uncertainty is retained in evidence. This verifies the central score at its source location, not every metadata field or an experimental reproduction.; evidence: {"table_xml_id": "Tab1", "row_cells": ["Mean", "×", "0.6794 ± 0.02", "1.0777 ± 0.04", "0.6576 ± 0.04", "0.5807 ± 0.03", "0.0248 ± 0.01", "1.7519 ± 0.01", "0.0967 ± 0.02", "1.0221 ± 0.01"], "selected_cell_zero_based": 6, "selected_cell_xml": "<td align=\"left\" colspan=\"1\" rowspan=\"1\">0.0248 ± 0.01</td>", "caption": "Benchmarking PRIME across different model scales and validation regimes for mutated RBD binding and expression"}; artifact sha256: f6aac4c25dd93026f87ce9a2e327c95faf4c3014d7f9ae04bb11f208ce047971; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13425921/fullTextXML
legacy id: lit-021
legacy row: id: lit-021; paper id: prime-2026; domain id: proteins-complexes; task: Mutated RBD binding prediction; model: ESM-2; model version: 8M; dataset: PRIME mutated RBD; dataset version: Not reported; split: position-stratified; metric: R²; value: 0.0248; unit: unitless; uncertainty: ± 0.01; protocol: Frozen mean-pooled representation with downstream regression; position-stratified split.; source locator: Table 1, ESM-2 8M / Mean / not fine-tuned row, Position-Stratified Split Binding R² column; source url: https://pmc.ncbi.nlm.nih.gov/articles/PMC13425921/; evaluation origin: independent_paper; reviewed utc: 2026-09-15T23:25:00Z
missing metadata: dataset version: not_reported_in_legacy_extract

Related records

evaluation: ESM-2: Mutated RBD binding prediction
subject: Reported R² for ESM-2

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