11 mean recovered known pathogenic events at 30 samples
FRASER (2021 article implementation) mean recovered known pathogenic events at 30 samples
- Tested configuration
- FRASER (2021 article implementation)
- Protocol
- FRASER Kremer cohort known pathogenic-event subsampling
- Dataset
- Kremer rare mitochondrial-disorder skin-fibroblast RNA cohort
- Procedure
- Randomly remove samples without known pathogenic splicing defect; measure fraction of 13 known events recovered at reduced cohort size. At 30 samples, 85% / mean 11 of 13; 100 samples needed to recover all irrespective of selected samples. FRASER controls latent confounding and models beta-binomial count fractions; cohort analysis uses FDR<0.1 and |effect|>0.3.
- Evaluation
- FRASER (2021 article implementation) evaluation
- Coverage
- scored: unreported; eligible: unreported
- Uncertainty
- Not reported
- Evidence
- Author-reported evaluation · source checkedDetection of aberrant splicing events in RNA-seq data using FRASER · Results Par18; Supplementary Fig. S20 referenced
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- retrospective sample-size subsampling
- Adaptation
- Not reported
- Scoring implementation
- Not reported
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 11 Individual claims | Detection of aberrant splicing events in RNA-seq data using FRASER Results Par18; Supplementary Fig. S20 referenced Version: Europe PMC fullTextXML retrieved 2026-10-07T12:23:57.289375+00:00 | source checked automated source review · 2026-10-07T13:38:59Z author reported Audit detailsBounded transcription of a Codex-checked primary-source cell. No independent experimental reproduction or qualified human scientific review. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
View linked audit checks and correction history
Release 2026-10-07-1448159e6a81 · Record review: source checked
1 source records and release history
- Detection of aberrant splicing events in RNA-seq data using FRASER · Original source · Europe PMC fullTextXML retrieved 2026-10-07T12:23:57.289375+00:00
Technical metadata and extraction receipts
Stable ID: amp-oncology-rna-20261007-issue-12-result-fraser-2021-article-implementation-mean-recovered-known-pathogenic-events-at-30-samples
- metric
- mean recovered known pathogenic events at 30 samples
- metric direction
- higher
- missing metadata
- None recorded
- numeric value
- 11
- printed value
- 11
- review
- method: automated_source_review; notes: Bounded transcription of a Codex-checked primary-source cell. No independent experimental reproduction or qualified human scientific review.; reviewed at: 2026-10-07T13:38:59Z; reviewer: Claude Sonnet AMP-integration worker, bounded transcription of Codex-checked primary values (workbench/amp-supervision/primary-review.md, integration-review-corrections.md); pending qualified human scientific review
- source locator
- Results Par18; Supplementary Fig. S20 referenced
- uncertainty
- Not reported
- unit
- events
Related records
- evaluation: FRASER (2021 article implementation) evaluation