Result

0.28 auprc

AlphaGenome variant scores plus expressed-splice-site feature → Explainable Boosting Classifier: Supervised GTEx splicing-outlier prediction, auprc

Tested pipeline: AlphaGenome variant scores plus expressed-splice-site feature → Explainable Boosting Classifier
Protocol: Supervised GTEx splicing-outlier prediction (AlphaGenome paper)
Dataset subset: Supervised GTEx splicing-outlier prediction: evaluated data subset
Procedure: Fit an Explainable Boosting Classifier on the training/validation data and evaluate the held-out variants.
Evaluation: AlphaGenome variant scores plus expressed-splice-site feature → Explainable Boosting Classifier: Supervised GTEx splicing-outlier prediction
Coverage: scored: unreported; eligible: unreported
Uncertainty: Not reported
Evidence: Author-reported evaluation · source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!M7

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: needs review. Source checked does not mean independently reproduced.

Reproduction

Split: Supervised training chromosomes are 1,4,7,8,10,13,15; validation chromosomes 2,5,11,14,17,20,22,X; test chromosomes 3,6,9,12,16,18,19,21. This is downstream evaluation separation, not a held-out reference-genome claim for the distilled backbone.
Adaptation: AlphaGenome variant scores plus expressed-splice-site feature → Explainable Boosting Classifier
Scoring implementation: Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Access requirements and official instructions: Supervised GTEx splicing-outlier prediction (AlphaGenome paper)

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-09-29-06401fd5b220
Property and statement	Original source and location	Review and provenance
Reported result 0.28 Individual claims	AlphaGenome Nature 2026 supplementary comparison tables Original source ↗ 'Suppl Table 4 Variant performan'!M7 Version: Nature version of record, 28 January 2026 Retrieved: 2026-09-17T06:31:06.887921+00:00	source checked OOXML extraction and separate automated primary-source review · 2026-09-17 author reported Audit details Checked against a second extraction. Fixed-format display and exact stored decimals preserved separately. No experiment rerun. Field: `attributes.printed_value` Source artifact SHA-256: `833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154` Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx Inspected artifact Extraction artifact SHA-256: `833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154` Extraction artifact

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Sources and history

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Release 2026-09-29-06401fd5b220 · Record review: source checked

3 source records and release history

AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied

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Technical metadata and extraction receipts

Stable ID: alphagenome-2026-result-68a1cea316c9ed93

areas: dna-genomes
printed value: 0.28
printed value basis: Workbook number format 0.00
numeric value: 0.28299999999999997
raw xml value: 0.28299999999999997
workbook number format: 0.00
metric: auprc
metric direction: higher
unit: dimensionless
aggregation: Pooled auPRC across GTEx tissues after assigning positive variants their observed tissues and negatives tissues sampled to match the positive tissue distribution.
uncertainty: Not reported
scored count: Not reported
eligible count: Not reported
source cells: 'Suppl Table 4 Variant performan'!M7
source locator: 'Suppl Table 4 Variant performan'!M7
review: method: OOXML extraction and separate automated primary-source review; date: 2026-09-17; artifact sha256: 833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154; retrieval url: https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41586-025-10014-0/MediaObjects/41586_2025_10014_MOESM3_ESM.xlsx; note: Checked against a second extraction. Fixed-format display and exact stored decimals preserved separately. No experiment rerun.
missing metadata: uncertainty: unreported; scored count: unextracted; eligible count: unextracted; seeds: unreported
source warnings: None recorded

Related records

evaluation: AlphaGenome variant scores plus expressed-splice-site feature → Explainable Boosting Classifier: Supervised GTEx splicing-outlier prediction

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