reported_finding: reanalysis-kaschta-20261010-protocol-manual-vs-talos-219-reanalysis
Reported finding of Manual versus Talos reanalysis of 219 unresolved genomes after a mean 660 days (Kaschta et al. 2026)
All newly identified P/LP findings and clinically relevant VUS arose from updated variant-calling and interpretation pipelines, revised gene-disease validity evidence, newly published literature or GeneMatcher collaborations; none from correcting interpretive errors.
Descriptive fact transcribed from the pinned source.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
6 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Claimed field reported_finding Context-only references | Automated versus manual reanalysis in rare disease genomics Discussion 'Diagnostic Yield in the Context of Published Reanalysis Studies' P1 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Source location Discussion 'Diagnostic Yield in the Context of Published Reanalysis Studies' P1 Context-only references | Automated versus manual reanalysis in rare disease genomics Discussion 'Diagnostic Yield in the Context of Published Reanalysis Studies' P1 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Claimed value All newly identified P/LP findings and clinically relevant VUS arose from updated variant-calling and interpretation pipelines, revised gene-disease validity evidence, newly published literature or GeneMatcher collaborations; none from correcting interpretive errors. Context-only references | Automated versus manual reanalysis in rare disease genomics Discussion 'Diagnostic Yield in the Context of Published Reanalysis Studies' P1 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Description Descriptive fact transcribed from the pinned source. Context-only references | Automated versus manual reanalysis in rare disease genomics Discussion 'Diagnostic Yield in the Context of Published Reanalysis Studies' P1 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Relationship: subject reanalysis-kaschta-20261010-protocol-manual-vs-talos-219-reanalysis Context-only references | Automated versus manual reanalysis in rare disease genomics Discussion 'Diagnostic Yield in the Context of Published Reanalysis Studies' P1 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Name reported_finding: reanalysis-kaschta-20261010-protocol-manual-vs-talos-219-reanalysis Context-only references | Automated versus manual reanalysis in rare disease genomics Discussion 'Diagnostic Yield in the Context of Published Reanalysis Studies' P1 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
Sources and history
Release 2026-10-10-457d7eaef7d6 · Record review: source checked
1 source record and release history
- Automated versus manual reanalysis in rare disease genomics · Original source · medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML
Technical metadata and extraction receipts
Stable ID: reanalysis-kaschta-20261010-claim-drivers-of-new-findings
- field
- reported_finding
- value
- All newly identified P/LP findings and clinically relevant VUS arose from updated variant-calling and interpretation pipelines, revised gene-disease validity evidence, newly published literature or GeneMatcher collaborations; none from correcting interpretive errors.
- source locator
- Discussion 'Diagnostic Yield in the Context of Published Reanalysis Studies' P1
- review
- method: source-hash-verification; ai-assisted-source-review; method note: Re-downloaded the JATS XML, matched its SHA-256 and compared the claim with the cited paragraphs.; reviewer: claude; reviewer note: Separate Claude review agent, independent of the extractor; no human review claimed; date: 2026-10-10; artifact sha256: db4ed16a501eda14ba114f8693f39596b03d7afaeafa8adafa41d84d9a61f6bd; retrieval url: https://www.medrxiv.org/content/early/2026/05/19/2026.05.16.26352295.source.xml; note: Independent review 2026-10-10: Matches Discussion 'Diagnostic Yield in the Context of Published Reanalysis Studies' P1, which says the new findings arose 'exclusively' from these sources.